{"id":"W4214859401","doi":"10.1182/blood.2022015789","title":"CAR T cells as a second-line therapy for large B-cell lymphoma: a paradigm shift?","year":2022,"lang":"en","type":"review","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":164,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC; University of British Columbia","funders":"","keywords":"Medicine; Chimeric antigen receptor; Oncology; Lymphoma; Internal medicine; Chemotherapy; Autologous stem-cell transplantation; Transplantation; Refractory (planetary science); Cell therapy; Surgery; Stem cell; Immunotherapy; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001176648,0.0006003693,0.001845771,0.001341036,0.0001671429,0.001084808,0.00107888,0.001403722,0.002910512],"category_scores_gemma":[0.001126784,0.0002177542,0.0007576733,0.001325256,0.0004363143,0.001412352,0.0004379546,0.002301181,0.001372551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005655928,"about_ca_system_score_gemma":0.001213037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008132604,"about_ca_topic_score_gemma":0.001836237,"domain_scores_codex":[0.9997839,0.00006767017,0.00003310327,0.00003544366,0.00006035114,0.00001950891],"domain_scores_gemma":[0.9995756,0.0002515426,0.00005446717,0.00001017651,0.00008462858,0.00002367642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002215559,0.0000695501,0.00009414616,0.04522893,0.0002516581,0.0001449832,0.00005494153,0.0003191721,0.001162282,0.005052886,0.02939254,0.9180073],"study_design_scores_gemma":[0.0002003726,0.0003369869,0.0006783861,0.0208124,0.0006206965,0.001255335,0.00009441646,0.0001329038,0.0004117529,0.002841855,0.9725894,0.00002557523],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007531463,0.9989223,0.00004477048,0.0004352749,0.0001932839,0.000004464907,0.000009534613,0.000002909535,0.0003121335],"genre_scores_gemma":[0.0005027739,0.9985529,0.0001145748,0.0004946342,0.0001175266,0.00000927654,0.00001513957,0.000001205644,0.0001920179],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002910512,"threshold_uncertainty_score":0.009736657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05866480215393918,"score_gpt":0.3534623504236394,"score_spread":0.2947975482697002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}