{"id":"W4214859401","doi":"10.1182/blood.2022015789","title":"CAR T cells as a second-line therapy for large B-cell lymphoma: a paradigm shift?","year":2022,"lang":"en","type":"review","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":164,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC; University of British Columbia","funders":"","keywords":"Medicine; Chimeric antigen receptor; Oncology; Lymphoma; Internal medicine; Chemotherapy; Autologous stem-cell transplantation; Transplantation; Refractory (planetary science); Cell therapy; Surgery; Stem cell; Immunotherapy; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001026607,0.0007968589,0.002884171,0.0004313692,0.0002149746,0.0000692766,0.0006535575,0.0005133056,0.03150058],"category_scores_gemma":[0.0000451972,0.0006591231,0.001909081,0.0006406135,0.00005620445,0.00004582318,0.0001962345,0.0007569274,0.0003854455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002870576,"about_ca_system_score_gemma":0.002129325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003181754,"about_ca_topic_score_gemma":0.00001348024,"domain_scores_codex":[0.9958397,0.0003312681,0.0008663148,0.001055113,0.0008116149,0.001095972],"domain_scores_gemma":[0.9969702,0.0007959298,0.0003464485,0.001423188,0.00004593191,0.0004182692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007213663,0.01628815,0.000003352826,0.04167189,0.003233835,0.001038097,0.0005535907,5.413077e-8,0.0003991988,0.0004898656,0.006160651,0.92944],"study_design_scores_gemma":[0.0223082,0.002071805,5.779756e-7,0.0009869192,0.00160779,0.000316934,0.00001976028,0.000001866372,0.0007758333,0.0001634729,0.9711833,0.0005635425],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004243567,0.9840034,0.00001037102,0.00008381525,0.0004028777,0.006479158,0.0009336459,0.0001418231,0.0075206],"genre_scores_gemma":[0.00003331796,0.9583578,0.00009668014,0.0004650617,0.001124458,0.002702152,0.001176537,0.0003839668,0.03566007],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9650226,"threshold_uncertainty_score":0.999586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05866480215393918,"score_gpt":0.3534623504236394,"score_spread":0.2947975482697002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}