{"id":"W4214860259","doi":"10.1083/jcb.201808181","title":"Fyn and TOM1L1 are recruited to clathrin-coated pits and regulate Akt signaling","year":2022,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Dalhousie University; Hospital for Sick Children; University of Toronto; Toronto Metropolitan University","funders":"Biotechnology and Biological Sciences Research Council; Ryerson University; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Ontario Ministry of Research, Innovation and Science; Canada Research Chairs","keywords":"FYN; Cell biology; Protein kinase B; Clathrin; Phosphorylation; Endocytosis; Signal transduction; Proto-oncogene tyrosine-protein kinase Src; Epidermal growth factor; PI3K/AKT/mTOR pathway; Epidermal growth factor receptor; Signal transducing adaptor protein; Cancer research; Biology; Chemistry; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000147994,0.0003239883,0.0001914246,0.0002850865,0.0004074729,0.000396413,0.0001899897,0.0003394993,0.001144874],"category_scores_gemma":[0.0001254742,0.0001999723,0.0002170689,0.0001303112,0.000225821,0.0003413076,0.0003663532,0.0003462408,0.0004760507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009340126,"about_ca_system_score_gemma":0.0003490118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001238023,"about_ca_topic_score_gemma":0.0015114,"domain_scores_codex":[0.9998651,0.00001146458,0.000006714757,0.00002714955,0.00003267455,0.00005693984],"domain_scores_gemma":[0.999927,0.000003476842,0.00002469859,0.000003518645,0.0000108434,0.00003038208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003184264,0.00001911666,0.001404102,0.00006808918,0.000007111428,0.0001464723,0.0000383655,0.00009915783,0.9936252,0.0006513431,0.0002394286,0.003383282],"study_design_scores_gemma":[0.00006530344,0.0001183925,0.05923598,0.00002399897,0.00002158848,0.001058839,0.000119376,0.004421753,0.9232849,0.0004517454,0.01118013,0.0000180876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906639,0.003941786,0.002503081,0.0002054703,0.00003649262,0.00002534881,0.0004449214,0.00008183555,0.002097107],"genre_scores_gemma":[0.9934207,0.001119429,0.001529201,0.00005136957,0.00001227614,0.00003740592,0.0005912733,0.00001648827,0.00322181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001238023,"threshold_uncertainty_score":0.00677681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0121616132049351,"score_gpt":0.2237393156396178,"score_spread":0.2115777024346827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}