{"id":"W4214860259","doi":"10.1083/jcb.201808181","title":"Fyn and TOM1L1 are recruited to clathrin-coated pits and regulate Akt signaling","year":2022,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Dalhousie University; Hospital for Sick Children; University of Toronto; Toronto Metropolitan University","funders":"Biotechnology and Biological Sciences Research Council; Ryerson University; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Ontario Ministry of Research, Innovation and Science; Canada Research Chairs","keywords":"FYN; Cell biology; Protein kinase B; Clathrin; Phosphorylation; Endocytosis; Signal transduction; Proto-oncogene tyrosine-protein kinase Src; Epidermal growth factor; PI3K/AKT/mTOR pathway; Epidermal growth factor receptor; Signal transducing adaptor protein; Cancer research; Biology; Chemistry; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005569042,0.00009552778,0.000158185,0.00005847354,0.0001435341,0.000007128569,0.0001356408,0.00007330212,0.00003974243],"category_scores_gemma":[0.00001517991,0.00006974691,0.00004446364,0.00007727082,0.0000604191,0.000002242252,0.00009478213,0.0001711609,6.111909e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009017466,"about_ca_system_score_gemma":0.00002636036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000837517,"about_ca_topic_score_gemma":0.000009693204,"domain_scores_codex":[0.9992483,0.0001802584,0.0002358539,0.000123086,0.00006550797,0.0001470002],"domain_scores_gemma":[0.9995254,0.00002221248,0.0001911531,0.0001181995,0.0000685335,0.00007452223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004479469,0.00001640624,0.001117673,0.000006298373,0.00002854835,0.000007350412,0.0002215296,0.0001803453,0.9973975,0.00001118111,0.0000496893,0.0005154716],"study_design_scores_gemma":[0.001023569,0.0017585,0.003393026,0.00001345107,0.00008382324,0.0003094845,0.0005899422,0.00007222148,0.9174743,0.0002476715,0.07484061,0.0001933711],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952539,0.002919543,0.001091422,0.0003964646,0.0001259879,0.0001018563,0.000009293258,0.000002858092,0.00009870279],"genre_scores_gemma":[0.9986797,0.000492362,0.00009749398,0.0003288522,0.0001049436,0.000001842557,0.00007228383,0.00001041014,0.0002121005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07992323,"threshold_uncertainty_score":0.2844197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0121616132049351,"score_gpt":0.2237393156396178,"score_spread":0.2115777024346827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}