{"id":"W4214860642","doi":"10.1016/j.jbc.2022.101796","title":"Mechanisms tailoring the expression of heat shock proteins to proteostasis challenges","year":2022,"lang":"en","type":"review","venue":"Journal of Biological Chemistry","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":166,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada","keywords":"Proteostasis; Heat shock protein; Cell biology; Heat shock; Shock (circulatory); Chemistry; Biology; Biochemistry; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000333024,0.0008272743,0.001096185,0.001612799,0.0002418048,0.0008935461,0.0008338633,0.0008293497,0.00271814],"category_scores_gemma":[0.0003291543,0.0003031479,0.0003748006,0.001341941,0.0003964418,0.001138165,0.0005689372,0.001481558,0.002421073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005463483,"about_ca_system_score_gemma":0.0005847053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004290563,"about_ca_topic_score_gemma":0.0007183463,"domain_scores_codex":[0.9998916,0.00001327321,0.0000134061,0.00002369279,0.0000403633,0.0000175922],"domain_scores_gemma":[0.9998833,0.00004043585,0.00001752464,0.000006133344,0.00003645009,0.00001615961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009265609,0.00009118445,0.0001639779,0.01696942,0.00008959313,0.0002379132,0.00006349906,0.0007814045,0.01491127,0.01053523,0.02178042,0.9342834],"study_design_scores_gemma":[0.00001218617,0.00009540597,0.0005539404,0.001167341,0.00005902614,0.0006524778,0.00002951776,0.0001413244,0.002896591,0.002102255,0.9922725,0.00001735726],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002999328,0.9972599,0.000352396,0.0001805506,0.0002539297,0.000007285299,0.00002251816,0.00001782798,0.001605666],"genre_scores_gemma":[0.001090537,0.9976062,0.0002658396,0.0001091857,0.00009244772,0.000008589258,0.00003539018,0.000002093335,0.0007897255],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00271814,"threshold_uncertainty_score":0.009093106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1180873792976048,"score_gpt":0.3551345198537841,"score_spread":0.2370471405561792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}