{"id":"W4214863373","doi":"10.1101/2022.03.01.22271652","title":"Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium","year":2022,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Hemispheric Asymmetry in Neuroscience","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Dalhousie University; Montreal Neurological Institute and Hospital; University of Toronto; Centre for Addiction and Mental Health","funders":"National Center for Advancing Translational Sciences; Faculty of Medicine and Health, University of Sydney; European Social Fund; Consejo Superior de Investigaciones Científicas; National Health and Medical Research Council; Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; Macquarie Group Foundation; Instituto de Física de Cantabria; Amsterdam Neuroscience; Amsterdam University Medical Centers; Norges Forskningsråd; Australian Schizophrenia Research Bank; Ramsay Health Care; Diakonhjemmet; University of Cape Town; NSW Ministry of Health; Universiteit Utrecht; Vetenskapsrådet; Instituto de Salud Carlos III; National Research Foundation of Korea; Korea Health Industry Development Institute; Deutsche Forschungsgemeinschaft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Ministero della Salute; Universidad de Cantabria; Queensland Brain Institute; Karolinska Institutet; University of Queensland; University of Toronto; U.S. Department of Veterans Affairs; University of New South Wales; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; University of Edinburgh; New Partnership for Africa's Development; Departamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS); National Institute for Health and Care Research; National Research Foundation; Pratt Foundation; Universitetet i Oslo; Ministerio de Ciencia e Innovación; Ministerstvo Zdravotnictví Ceské Republiky; Erasmus Universitair Medisch Centrum Rotterdam; European Commission; European Regional Development Fund; King's College London; Max-Planck-Gesellschaft; Korea Brain Research Institute; National Institute for Physiological Sciences; Vrije Universiteit Amsterdam; Neuroscience Research Australia; South African Medical Research Council; National Institute of Mental Health; Helse Sør-Øst RHF; Hunter Medical Research Institute; Centro de Investigación Biomédica en Red de Salud Mental; ZonMw; National Center for Research Resources; National Alliance for Research on Schizophrenia and Depression; Novartis Foundation; Centre for Addiction and Mental Health Foundation; Instituto de Investigación Marqués de Valdecilla; Pfizer; Sylvia and Charles Viertel Charitable Foundation; Brain and Behavior Research Foundation; National Science Foundation","keywords":"Context (archaeology); Schizophrenia (object-oriented programming); Psychology; Lateralization of brain function; Neuroscience; Asymmetry; Biology; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01994149,0.001490372,0.002729339,0.007990349,0.001907004,0.003028061,0.00280013,0.001458396,0.00516801],"category_scores_gemma":[0.038823,0.001096309,0.003608776,0.009118151,0.001181277,0.001128567,0.006222619,0.001175643,0.0007981821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009053905,"about_ca_system_score_gemma":0.001901274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01175671,"about_ca_topic_score_gemma":0.0123104,"domain_scores_codex":[0.9854339,0.006741446,0.001246423,0.004223655,0.001538017,0.0008165062],"domain_scores_gemma":[0.9734471,0.008598237,0.006154463,0.00754955,0.002865277,0.00138545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005036164,0.0001518041,0.8250983,0.003802906,0.07431008,0.002096514,0.001329677,0.00572472,0.0111528,0.004972272,0.0264811,0.03984363],"study_design_scores_gemma":[0.0008290005,0.0002407525,0.9415149,0.0007848553,0.0209434,0.002722292,0.0005314536,0.004444119,0.002267283,0.006363027,0.01910352,0.0002554097],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8648265,0.01384893,0.02974477,0.001445472,0.0002481795,0.0004409859,0.0853283,0.001019576,0.003097253],"genre_scores_gemma":[0.9210446,0.001889047,0.01805371,0.0002911916,0.0001375875,0.00145434,0.05559328,0.0008133783,0.0007228743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01994149,"threshold_uncertainty_score":0.105462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02204362488258884,"score_gpt":0.2936185653292445,"score_spread":0.2715749404466556,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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