{"id":"W4214863373","doi":"10.1101/2022.03.01.22271652","title":"Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium","year":2022,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Hemispheric Asymmetry in Neuroscience","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Dalhousie University; Montreal Neurological Institute and Hospital; University of Toronto; Centre for Addiction and Mental Health","funders":"National Center for Advancing Translational Sciences; Faculty of Medicine and Health, University of Sydney; European Social Fund; Consejo Superior de Investigaciones Científicas; National Health and Medical Research Council; Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; Macquarie Group Foundation; Instituto de Física de Cantabria; Amsterdam Neuroscience; Amsterdam University Medical Centers; Norges Forskningsråd; Australian Schizophrenia Research Bank; Ramsay Health Care; Diakonhjemmet; University of Cape Town; NSW Ministry of Health; Universiteit Utrecht; Vetenskapsrådet; Instituto de Salud Carlos III; National Research Foundation of Korea; Korea Health Industry Development Institute; Deutsche Forschungsgemeinschaft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Ministero della Salute; Universidad de Cantabria; Queensland Brain Institute; Karolinska Institutet; University of Queensland; University of Toronto; U.S. Department of Veterans Affairs; University of New South Wales; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; University of Edinburgh; New Partnership for Africa's Development; Departamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS); National Institute for Health and Care Research; National Research Foundation; Pratt Foundation; Universitetet i Oslo; Ministerio de Ciencia e Innovación; Ministerstvo Zdravotnictví Ceské Republiky; Erasmus Universitair Medisch Centrum Rotterdam; European Commission; European Regional Development Fund; King's College London; Max-Planck-Gesellschaft; Korea Brain Research Institute; National Institute for Physiological Sciences; Vrije Universiteit Amsterdam; Neuroscience Research Australia; South African Medical Research Council; National Institute of Mental Health; Helse Sør-Øst RHF; Hunter Medical Research Institute; Centro de Investigación Biomédica en Red de Salud Mental; ZonMw; National Center for Research Resources; National Alliance for Research on Schizophrenia and Depression; Novartis Foundation; Centre for Addiction and Mental Health Foundation; Instituto de Investigación Marqués de Valdecilla; Pfizer; Sylvia and Charles Viertel Charitable Foundation; Brain and Behavior Research Foundation; National Science Foundation","keywords":"Context (archaeology); Schizophrenia (object-oriented programming); Psychology; Lateralization of brain function; Neuroscience; Asymmetry; Biology; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001692977,0.0004861898,0.001020677,0.0008102871,0.0003608835,0.0001216703,0.003110772,0.0002075281,0.000846522],"category_scores_gemma":[0.005689744,0.0003859575,0.0005001699,0.008022695,0.0008876292,0.0001400497,0.003102597,0.001809638,0.000008524607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001460751,"about_ca_system_score_gemma":0.0002819386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001323037,"about_ca_topic_score_gemma":0.0002309549,"domain_scores_codex":[0.9937083,0.001364604,0.001091371,0.001573035,0.001497116,0.0007655504],"domain_scores_gemma":[0.9946723,0.002359236,0.0007972625,0.001960456,0.00006432918,0.0001464032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002835586,0.0003127957,0.6344787,0.0002078004,0.0002188643,0.0002478202,0.005341022,0.03248149,0.3214568,0.002603404,0.0003929602,0.001974697],"study_design_scores_gemma":[0.0008555639,0.0001076618,0.653702,0.00003859579,0.0004891054,0.00002681995,0.0007733995,0.1362013,0.2012229,0.001912379,0.003649075,0.001021183],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943043,0.0001370697,0.001124561,0.00108562,0.001345948,0.000549016,0.0003646434,0.00009337665,0.0009954605],"genre_scores_gemma":[0.9977835,0.00003388586,0.0003353225,0.001171053,0.00005324402,0.000104779,0.00001647939,0.00004264892,0.0004590294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1202339,"threshold_uncertainty_score":0.9998592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02204362488258884,"score_gpt":0.2936185653292445,"score_spread":0.2715749404466556,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}