{"id":"W4214863719","doi":"10.1055/s-0040-1719862","title":"N-Amino-imidazol-2-one (Nai) Residues as Tools for Peptide Mimicry: Synthesis, Conformational Analysis and Biomedical Applications","year":2022,"lang":"en","type":"article","venue":"Synthesis","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Conformational isomerism; Residue (chemistry); Dihedral angle; Peptide; Side chain; Stereochemistry; Biochemistry; Molecule; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001947771,0.0003596972,0.0002277274,0.0001970927,0.0001073285,0.000320742,0.0002388362,0.0002860386,0.0005613637],"category_scores_gemma":[0.0002094247,0.0001466946,0.000150686,0.0001632225,0.0002774585,0.0003095244,0.0001633299,0.0003949192,0.0003742995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004398157,"about_ca_system_score_gemma":0.0001584139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002095524,"about_ca_topic_score_gemma":0.0004168888,"domain_scores_codex":[0.999934,0.00001304276,0.00000509215,0.00001725244,0.00002365128,0.00000700786],"domain_scores_gemma":[0.9999428,0.00001609787,0.00002022273,0.000004860694,0.000009353013,0.000006716386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001089668,0.00002910172,0.0001390943,0.0006635205,0.000009068073,0.0001224362,0.00003518687,0.001710653,0.9638442,0.004661473,0.0003440048,0.0283323],"study_design_scores_gemma":[0.00003880019,0.0006534916,0.000642879,0.00007151825,0.0000260991,0.0005893522,0.00002698119,0.002655089,0.946568,0.001487492,0.04720958,0.00003071948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5737835,0.2863708,0.1049534,0.001427236,0.0007322962,0.0002589687,0.0005806015,0.0004650022,0.03142824],"genre_scores_gemma":[0.8322399,0.09988736,0.0558581,0.0003414617,0.0001225316,0.0001603633,0.0002676877,0.00005645783,0.01106614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005613637,"threshold_uncertainty_score":0.003191173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01174231455654887,"score_gpt":0.2493513214161461,"score_spread":0.2376090068595972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}