{"id":"W4214863719","doi":"10.1055/s-0040-1719862","title":"N-Amino-imidazol-2-one (Nai) Residues as Tools for Peptide Mimicry: Synthesis, Conformational Analysis and Biomedical Applications","year":2022,"lang":"en","type":"article","venue":"Synthesis","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Conformational isomerism; Residue (chemistry); Dihedral angle; Peptide; Side chain; Stereochemistry; Biochemistry; Molecule; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005078851,0.0002249219,0.0004347809,0.0002315234,0.0005057851,0.00009552394,0.0003581369,0.0001311408,0.0007795489],"category_scores_gemma":[0.000952372,0.000226903,0.0004242053,0.0004781148,0.0001820229,0.00001422916,0.000257897,0.00009982144,0.00001317365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004478265,"about_ca_system_score_gemma":0.00008786094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006597587,"about_ca_topic_score_gemma":0.00002876662,"domain_scores_codex":[0.9981858,0.0001024569,0.0004439426,0.0005690102,0.0003628455,0.0003359336],"domain_scores_gemma":[0.9983324,0.0007390587,0.0001898437,0.0004685354,0.00008830008,0.0001818988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002512598,0.000515162,0.002089262,0.0001091258,0.003611351,0.000001760565,0.00008412693,0.00007735424,0.9129654,0.001199931,0.004999226,0.07409599],"study_design_scores_gemma":[0.0003007301,0.0001194491,0.002823718,0.00001550444,0.00270015,0.00001665431,0.0008795651,0.0004790081,0.7105511,0.0006092082,0.2808667,0.0006381902],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9672917,0.001184721,0.02099373,0.004236882,0.00004403751,0.0008703196,0.00220358,0.00007517042,0.00309988],"genre_scores_gemma":[0.9921866,0.0002406441,0.003589235,0.0003352878,0.000203921,0.002345983,0.0007063811,0.0000295477,0.0003623732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2758675,"threshold_uncertainty_score":0.9252836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01174231455654887,"score_gpt":0.2493513214161461,"score_spread":0.2376090068595972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}