{"id":"W4214865535","doi":"10.1186/s13063-022-06115-0","title":"LIBERATE: a study protocol for midodrine for the early liberation from vasopressor support in the intensive care unit (LIBERATE): protocol for a randomized controlled trial","year":2022,"lang":"en","type":"article","venue":"Trials","topic":"Sepsis Diagnosis and Treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Health Services; University of Calgary; University of Alberta","funders":"","keywords":"Medicine; Midodrine; Intensive care unit; Randomized controlled trial; Discontinuation; Placebo; Intensive care medicine; Anesthesia; Emergency medicine; Surgery; Blood pressure; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04224874,0.007645838,0.01242317,0.002964048,0.003669081,0.006752357,0.004130997,0.008145196,0.1135676],"category_scores_gemma":[0.05666157,0.00364391,0.006471591,0.0050164,0.003937434,0.003982877,0.002413185,0.01117168,0.02262068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.007231073,"about_ca_system_score_gemma":0.01748611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002065901,"about_ca_topic_score_gemma":0.004343939,"domain_scores_codex":[0.9650694,0.02379161,0.003491876,0.00275719,0.002604345,0.002285563],"domain_scores_gemma":[0.9736317,0.008395942,0.00551447,0.003841095,0.006030586,0.002586227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7607313,0.007848707,0.0006414034,0.06269281,0.003683173,0.0003587856,0.0007123381,0.002225883,0.003321609,0.0132262,0.1057494,0.03880854],"study_design_scores_gemma":[0.8697213,0.007928792,0.00133324,0.01019442,0.0009262307,0.0001022217,0.0001361838,0.003244763,0.001105801,0.006023676,0.09913038,0.0001529004],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.00061614,0.0003492517,0.00170788,0.0002670785,0.0006399667,0.9929906,0.002346989,0.0002035998,0.000878497],"genre_scores_gemma":[0.0005935259,0.0001061875,0.001994548,0.000158576,0.00005330883,0.9964058,0.0002447977,0.00001850668,0.0004247525],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.1135676,"threshold_uncertainty_score":0.3799214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2948155198231912,"score_gpt":0.4940579463329471,"score_spread":0.199242426509756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}