{"id":"W4214872783","doi":"10.1002/hep4.1918","title":"A multi‐analyte cell‐free DNA–based blood test for early detection of hepatocellular carcinoma","year":2022,"lang":"en","type":"article","venue":"Hepatology Communications","topic":"Hepatocellular Carcinoma Treatment and Prognosis","field":"Medicine","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"National Cancer Institute; Agios Pharmaceuticals; AstraZeneca; Bristol-Myers Squibb","keywords":"Medicine; Hepatocellular carcinoma; Internal medicine; Confidence interval; Receiver operating characteristic; Stage (stratigraphy); Gastroenterology; Blood test; Guideline; Prospective cohort study; Oncology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002766287,0.000374844,0.0004191927,0.001084502,0.0001827666,0.0004802381,0.0003850199,0.0004981254,0.0005406677],"category_scores_gemma":[0.005441515,0.000216575,0.0002326973,0.0004691918,0.0002870177,0.0004182957,0.000385813,0.0004149299,0.0003169753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002176345,"about_ca_system_score_gemma":0.0002595346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004551974,"about_ca_topic_score_gemma":0.0006735515,"domain_scores_codex":[0.9983428,0.0008198874,0.0001176081,0.0003412149,0.0003097989,0.00006881029],"domain_scores_gemma":[0.9969958,0.001301111,0.00078788,0.0002641046,0.000424659,0.0002264291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002032048,0.0002743746,0.923202,0.00009567507,0.0002258785,0.0001132717,0.0001046646,0.0008029768,0.02580821,0.0001077471,0.000461964,0.04677105],"study_design_scores_gemma":[0.0001975075,0.004471677,0.970512,0.00003605196,0.0001776272,0.001359149,0.000089059,0.0054722,0.01589053,0.000165227,0.001583295,0.00004569489],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914542,0.002618974,0.004010787,0.0001574617,0.00002727604,0.00008718516,0.0004689355,0.0000807265,0.001094348],"genre_scores_gemma":[0.9950981,0.0002444186,0.003903774,0.0000966656,0.00002249746,0.00004255508,0.0003437886,0.000005222713,0.0002429929],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002766287,"threshold_uncertainty_score":0.01462966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0769616329353375,"score_gpt":0.2690984349271424,"score_spread":0.1921368019918049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}