{"id":"W4214873425","doi":"10.1101/2022.03.02.482651","title":"Intranasal Immunization with a Proteosome-Adjuvanted SARS-CoV2 Spike Protein-Based Vaccine is Immunogenic and Efficacious in Mice & Hamsters","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xerox (Canada); Merck Canada Inc. (Canada); National Research Council Canada","funders":"","keywords":"Immunogenicity; Nasal administration; Adjuvant; Virology; Immunization; Medicine; Immune system; Immunology; Vaccine efficacy; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002929268,0.0004690653,0.0004195109,0.0003294227,0.0001230717,0.0002757814,0.0001568272,0.0004608532,0.001547958],"category_scores_gemma":[0.0001009595,0.0001477581,0.0002669476,0.0001216703,0.0002244643,0.000233381,0.0001474481,0.000647872,0.0005096659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002469255,"about_ca_system_score_gemma":0.0002629817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006373067,"about_ca_topic_score_gemma":0.0006053376,"domain_scores_codex":[0.999833,0.00002346812,0.00001141333,0.00004281632,0.00004031626,0.00004896908],"domain_scores_gemma":[0.9999304,0.000008866458,0.00001954937,0.00001011993,0.00001239393,0.00001862568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002059917,0.000135853,0.00009235546,0.00002869403,0.000006295246,0.00001948296,0.00001128008,0.00009813372,0.9979535,0.00007029324,0.00009623216,0.001281763],"study_design_scores_gemma":[0.00005451679,0.002023962,0.001396108,0.000008854093,0.00001834116,0.00009330525,0.00001422985,0.001125796,0.9930978,0.000054168,0.002108778,0.000004174029],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908303,0.001016527,0.004329246,0.0001797323,0.000115928,0.0001007882,0.0006795282,0.0001650137,0.002583102],"genre_scores_gemma":[0.9837813,0.0008228078,0.004952143,0.0001379283,0.00004256116,0.00009444019,0.001002394,0.00004901489,0.00911742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001547958,"threshold_uncertainty_score":0.005178452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01722697531067017,"score_gpt":0.2645528471209326,"score_spread":0.2473258718102624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}