{"id":"W4214884121","doi":"10.1101/2022.03.02.482704","title":"AMP-activated protein kinase (AMPK) is required for recovery from metabolic stress induced by ultrasound microbubble treatment","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; McGill University Health Centre; McGill University; Toronto Metropolitan University","funders":"Government of Ontario; McGill University","keywords":"AMPK; Protein kinase A; AMP-activated protein kinase; Cell biology; Cancer cell; mTORC1; Endocytosis; Glycolysis; Chemistry; Cell; Programmed cell death; Cellular adaptation; Kinase; Cancer research; Apoptosis; Biology; Signal transduction; Biochemistry; Cancer; PI3K/AKT/mTOR pathway; Metabolism; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007775817,0.0001549719,0.0002289428,0.0001098049,0.0001188745,0.0002801669,0.0000972202,0.0002491232,0.001281826],"category_scores_gemma":[0.0001266499,0.00009418738,0.0001363371,0.00008854728,0.0001612826,0.000131145,0.0001159648,0.0002967986,0.0003489251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002037688,"about_ca_system_score_gemma":0.0001143206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004876642,"about_ca_topic_score_gemma":0.0004513713,"domain_scores_codex":[0.9999197,0.00001233843,0.000008285122,0.00001520092,0.00002356372,0.00002081507],"domain_scores_gemma":[0.9999493,0.0000127018,0.00001342663,0.000007702342,0.000006423309,0.00001037981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005997402,0.000006067805,0.00009166696,0.00001258981,0.000001261615,0.00002897251,0.000005351409,0.00003646225,0.9993485,0.00005225931,0.00002370158,0.0003332683],"study_design_scores_gemma":[0.000005109302,0.00004955921,0.003212158,0.000002134907,0.000003105259,0.0001133368,0.00001813128,0.0007356533,0.9946316,0.00004058317,0.001185942,0.000002604922],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936725,0.001137286,0.003009502,0.00013725,0.00004723273,0.00001645182,0.0004107498,0.00006092891,0.001507996],"genre_scores_gemma":[0.9954335,0.0003996869,0.001628567,0.00004435402,0.000006128281,0.00001884237,0.0004943582,0.00002544381,0.001949047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001281826,"threshold_uncertainty_score":0.004288137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01886286015377541,"score_gpt":0.2203812159451948,"score_spread":0.2015183557914194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}