{"id":"W4214884454","doi":"10.1200/po.21.00286","title":"Immune Checkpoint Inhibition as Single Therapy for Synchronous Cancers Exhibiting Hypermutation: An IRRDC Study","year":2022,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Multiple and Secondary Primary Cancers","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"St. Baldrick's Foundation; Hospital for Sick Children; Bristol-Myers Squibb","keywords":"Somatic hypermutation; Immune checkpoint; Immune system; Medicine; Oncology; Immunology; Immunotherapy; Antibody; B cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001001428,0.0002046284,0.0005356231,0.0002055782,0.0005249488,0.00002454812,0.0001312044,0.0001032613,0.00279135],"category_scores_gemma":[0.0001417389,0.0001992905,0.0001645168,0.0002292141,0.00006217232,0.0001954785,0.0001093617,0.0003589166,0.00001678271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002880329,"about_ca_system_score_gemma":0.001256378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003902602,"about_ca_topic_score_gemma":0.0001192713,"domain_scores_codex":[0.9977201,0.0003222155,0.0006564577,0.0005712612,0.000385809,0.0003441091],"domain_scores_gemma":[0.9986372,0.0003621049,0.0002929512,0.0003887916,0.0001713227,0.0001476429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.008494086,0.002996937,0.0007527857,0.00003316373,0.0001467572,0.0002117997,0.00855598,0.001330487,0.2702861,0.00004362719,0.001251997,0.7058963],"study_design_scores_gemma":[0.07830066,0.2003094,0.03257021,0.0001182913,0.0003981896,0.001775985,0.06999581,0.009634104,0.08564609,0.001720945,0.5180873,0.001443024],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886605,0.000643334,0.0003915235,0.001133012,0.0009038496,0.002801484,0.00003508466,0.0001097063,0.005321475],"genre_scores_gemma":[0.9937724,0.00006127782,0.001468478,0.002121547,0.0003836579,0.001236815,0.0003113112,0.00005092027,0.000593525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7044533,"threshold_uncertainty_score":0.9981202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04808232243282154,"score_gpt":0.3559539374760146,"score_spread":0.307871615043193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}