{"id":"W4214884454","doi":"10.1200/po.21.00286","title":"Immune Checkpoint Inhibition as Single Therapy for Synchronous Cancers Exhibiting Hypermutation: An IRRDC Study","year":2022,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Multiple and Secondary Primary Cancers","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"St. Baldrick's Foundation; Hospital for Sick Children; Bristol-Myers Squibb","keywords":"Somatic hypermutation; Immune checkpoint; Immune system; Medicine; Oncology; Immunology; Immunotherapy; Antibody; B cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00124129,0.0006468481,0.001783667,0.0004606672,0.0003679324,0.0009309682,0.0006897837,0.0005155349,0.002714257],"category_scores_gemma":[0.0006635383,0.000261754,0.001339257,0.0005875506,0.0007310646,0.0005784619,0.0003254442,0.003121636,0.0005102494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007839156,"about_ca_system_score_gemma":0.001086541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001293313,"about_ca_topic_score_gemma":0.002281624,"domain_scores_codex":[0.9995615,0.0001209024,0.00002796779,0.000109141,0.00006129262,0.0001192148],"domain_scores_gemma":[0.9994913,0.0001064565,0.00007160535,0.000140526,0.0000357552,0.0001543338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.1694932,0.1172515,0.01615987,0.002149907,0.003151008,0.0009320009,0.0007998715,0.004897765,0.1274748,0.002306436,0.005236202,0.5501474],"study_design_scores_gemma":[0.07124248,0.8207244,0.02670569,0.0003083337,0.004445965,0.003543843,0.0004682466,0.003309074,0.04248068,0.0008048856,0.02588238,0.00008399379],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880233,0.006228924,0.0009620263,0.0002593851,0.0001214182,0.0005419569,0.0003692943,0.0000549957,0.003438773],"genre_scores_gemma":[0.9889287,0.006122461,0.001502008,0.0004884534,0.0001137896,0.0003255862,0.0006442766,0.00004852222,0.001826116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002714257,"threshold_uncertainty_score":0.009080052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04808232243282154,"score_gpt":0.3559539374760146,"score_spread":0.307871615043193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}