{"id":"W4214886362","doi":"10.1038/s41541-022-00449-1","title":"Centrin-deficient Leishmania mexicana confers protection against New World cutaneous leishmaniasis","year":2022,"lang":"en","type":"article","venue":"npj Vaccines","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill Genome Centre; McGill University","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Global Health Innovative Technology Fund","keywords":"Leishmania mexicana; Amastigote; Leishmania; Cutaneous leishmaniasis; Leishmaniasis; Biology; Leishmania major; Immunology; Immunogenicity; Cytokine; Leishmania tropica; Virology; Immune system; Parasite hosting","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003889487,0.0004217597,0.0007051814,0.0007390772,0.0008956905,0.00009189829,0.0003930837,0.00006579621,0.002305649],"category_scores_gemma":[0.0003622811,0.0003959638,0.0003537826,0.001444543,0.00006042769,0.0001391093,0.0005508192,0.0008563682,0.0001829607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000906128,"about_ca_system_score_gemma":0.0004871762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001246314,"about_ca_topic_score_gemma":0.00103956,"domain_scores_codex":[0.9961358,0.0001892455,0.0006005457,0.0008243782,0.001317272,0.0009327084],"domain_scores_gemma":[0.9981661,0.000111475,0.0002134397,0.0007476815,0.0002972169,0.0004640984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00411961,0.002174759,0.1095534,0.0006297169,0.001818284,0.002932835,0.002490235,0.002143165,0.03136135,0.002229513,0.629576,0.2109711],"study_design_scores_gemma":[0.00836194,0.003474844,0.05491767,0.0001983521,0.0005247907,0.001810778,0.004846549,0.002067065,0.01254768,0.000499164,0.9093692,0.001381946],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.930567,0.001777978,0.0001507664,0.02052421,0.001114335,0.003131299,0.00004567419,0.0006547027,0.04203409],"genre_scores_gemma":[0.9596962,0.0002558473,0.000262804,0.001302439,0.0006216607,0.0003389503,0.00004961664,0.00009726599,0.03737525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2797932,"threshold_uncertainty_score":0.9998492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03637937889199591,"score_gpt":0.2797422591567296,"score_spread":0.2433628802647337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}