{"id":"W4214898817","doi":"10.1080/14740338.2022.2047928","title":"Efficacy and safety of racemic ketamine and esketamine for depression: a systematic review and meta-analysis","year":2022,"lang":"en","type":"review","venue":"Expert Opinion on Drug Safety","topic":"Treatment of Major Depression","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; British Columbia Centre on Substance Use; University of Calgary","funders":"National Institute on Drug Abuse; National Institutes of Health","keywords":"Medicine; Ketamine; Placebo; Depression (economics); Adverse effect; Meta-analysis; Internal medicine; Confidence interval; Relative risk; Randomized controlled trial; Major depressive disorder; Anesthesia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001384679,0.0009186353,0.01205366,0.0005146895,0.0002233519,0.00002070215,0.0002133506,0.0002360959,0.0004854444],"category_scores_gemma":[0.0007917224,0.0005495335,0.001828233,0.0006054924,0.0001222112,0.00008364974,0.0003488585,0.0003790827,0.000002490962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001400264,"about_ca_system_score_gemma":0.00009280405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001308781,"about_ca_topic_score_gemma":0.000001289593,"domain_scores_codex":[0.994827,0.0008992155,0.002108539,0.00119713,0.0006587633,0.0003093789],"domain_scores_gemma":[0.9937873,0.003067083,0.001424405,0.00134513,0.00008221216,0.0002937931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004503922,0.0003995499,0.000003521108,0.8429338,0.08707736,0.00001077253,0.0001724589,6.982182e-7,7.528531e-7,0.00004881863,0.001372952,0.06752886],"study_design_scores_gemma":[0.002311759,0.0002592549,0.00001928293,0.07035465,0.3762171,0.0001657714,0.00003068802,0.00001406107,0.000001984683,0.000001620502,0.5502402,0.0003836889],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00000124255,0.9884111,0.00007182934,0.0008739034,0.0000991298,0.009956437,0.0004009497,0.00005931691,0.0001261179],"genre_scores_gemma":[0.00002188614,0.9941009,0.0007000761,0.0003507044,0.00006104293,0.002157427,0.001235206,0.0001000932,0.00127266],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7725792,"threshold_uncertainty_score":0.9996956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09425174148257835,"score_gpt":0.3945047461254357,"score_spread":0.3002530046428574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}