{"id":"W4214899573","doi":"10.3390/antibiotics11030335","title":"Effects of Lysine N-ζ-Methylation in Ultrashort Tetrabasic Lipopeptides (UTBLPs) on the Potentiation of Rifampicin, Novobiocin, and Niclosamide in Gram-Negative Bacteria","year":2022,"lang":"en","type":"article","venue":"Antibiotics","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Novobiocin; Chloramphenicol; Efflux; Antibiotics; Rifampicin; Membrane permeability; Chemistry; Tetracycline; Methylation; Long-term potentiation; Microbiology; Lysine; Bacteria; Biochemistry; Biology; Membrane; DNA; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001226269,0.0002685932,0.0001776958,0.00006988437,0.00006533603,0.0001074678,0.0001365535,0.0001860994,0.0005479727],"category_scores_gemma":[0.0002411178,0.0001186125,0.0001521121,0.00007404629,0.0001760955,0.0001730819,0.0001739376,0.0003521385,0.0001410776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001409222,"about_ca_system_score_gemma":0.0001265806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004905868,"about_ca_topic_score_gemma":0.0006176179,"domain_scores_codex":[0.999908,0.00002295384,0.00001284639,0.00001937024,0.00002089885,0.00001595618],"domain_scores_gemma":[0.9998222,0.00004324478,0.00006437176,0.00001157413,0.00001767485,0.00004095704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001516802,0.00001804861,0.00005642754,0.00002723632,0.000003825122,0.00002052863,0.000009658588,0.00006693751,0.9990264,0.000009949496,0.000005096226,0.0006041556],"study_design_scores_gemma":[0.00001048901,0.0006044186,0.0009382996,0.000003794328,0.000008253407,0.00005354446,0.000009423996,0.0003004665,0.9977244,0.000005796506,0.0003380184,0.000003195876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985375,0.0005463224,0.0004656239,0.00002425948,0.000009002859,0.00001763392,0.0000579713,0.00001167824,0.0003297935],"genre_scores_gemma":[0.9977344,0.0004870711,0.001254097,0.00002635275,0.000004103275,0.00001360857,0.00009736072,0.000006730696,0.0003761923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005479727,"threshold_uncertainty_score":0.001833141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005492521162471735,"score_gpt":0.2203760415150705,"score_spread":0.2148835203525987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}