{"id":"W4214899573","doi":"10.3390/antibiotics11030335","title":"Effects of Lysine N-ζ-Methylation in Ultrashort Tetrabasic Lipopeptides (UTBLPs) on the Potentiation of Rifampicin, Novobiocin, and Niclosamide in Gram-Negative Bacteria","year":2022,"lang":"en","type":"article","venue":"Antibiotics","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Novobiocin; Chloramphenicol; Efflux; Antibiotics; Rifampicin; Membrane permeability; Chemistry; Tetracycline; Methylation; Long-term potentiation; Microbiology; Lysine; Bacteria; Biochemistry; Biology; Membrane; DNA; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004091474,0.0001454901,0.0002391148,0.0001174358,0.00005108458,0.000009500583,0.000155574,0.00008635285,0.00001244419],"category_scores_gemma":[0.0003612785,0.0001251962,0.00005282277,0.0003117523,0.0001453099,0.000007861712,0.0000934435,0.0001457633,4.981222e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002977404,"about_ca_system_score_gemma":0.00004234041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001142126,"about_ca_topic_score_gemma":0.0001560596,"domain_scores_codex":[0.99877,0.0002276319,0.0003920014,0.0002711706,0.0001705123,0.0001686717],"domain_scores_gemma":[0.9992435,0.0001820031,0.0002440258,0.0002520503,0.0000581438,0.00002029792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001566299,0.0001817803,0.1541413,0.00008716181,0.00003106061,0.000003078919,0.000163064,0.0001639452,0.8442835,0.0002437596,0.00004786099,0.0004968049],"study_design_scores_gemma":[0.0003708661,0.0002647114,0.4542187,0.00005364982,0.00001388748,0.000001728834,0.0002414893,0.00006237036,0.5445629,0.0001048268,0.0000254839,0.00007939128],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989993,0.0001549119,0.00009349647,0.0001004627,0.00011332,0.000397754,0.00003071643,0.000003412262,0.0001066466],"genre_scores_gemma":[0.9990537,0.0002943829,0.0003978883,0.00007631294,0.00002798772,0.000001152292,0.0000807187,0.00001792823,0.00004995768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3000774,"threshold_uncertainty_score":0.5105353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005492521162471735,"score_gpt":0.2203760415150705,"score_spread":0.2148835203525987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}