{"id":"W4214900466","doi":"10.3389/fcvm.2022.791700","title":"Proteomic Analysis Suggests Altered Mitochondrial Metabolic Profile Associated With Diabetic Cardiomyopathy","year":2022,"lang":"en","type":"article","venue":"Frontiers in Cardiovascular Medicine","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; Alberta Bone and Joint Health Institute; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Cumming School of Medicine, University of Calgary","keywords":"Diabetic cardiomyopathy; Internal medicine; Mitochondrion; Downregulation and upregulation; Endocrinology; Mitochondrial respiratory chain; Biology; Protein subunit; Respiratory chain; ATP synthase; Cardiomyopathy; Chemistry; Cell biology; Medicine; Biochemistry; Heart failure; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000144459,0.0002771338,0.0002068411,0.0005965155,0.0001506486,0.000221405,0.00008807569,0.0002334985,0.0004511777],"category_scores_gemma":[0.0001020914,0.0001153352,0.0001981789,0.0003070497,0.0001141517,0.0001172382,0.0001775485,0.0002409099,0.000112559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008675887,"about_ca_system_score_gemma":0.00005709462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002145878,"about_ca_topic_score_gemma":0.0002295774,"domain_scores_codex":[0.9999269,0.000007657596,0.000009412771,0.00002283584,0.0000167157,0.00001650596],"domain_scores_gemma":[0.9998887,0.00001099617,0.00004356956,0.000005687505,0.00001641511,0.00003453816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001923418,0.00002240538,0.005000215,0.00004036212,0.00001723086,0.0001718294,0.00002200851,0.00001486924,0.9934573,0.00002097485,0.00002742313,0.001013241],"study_design_scores_gemma":[0.00002777958,0.0006179016,0.7040952,0.00003048966,0.0001462239,0.004706644,0.000242786,0.001369634,0.2867538,0.000195491,0.001791896,0.00002204952],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974612,0.0008592519,0.0009194042,0.00003270722,0.00001083568,0.000007596997,0.0003673882,0.00001605999,0.0003255686],"genre_scores_gemma":[0.995409,0.0008679514,0.001997672,0.0001032719,0.00001249122,0.00001551228,0.0008742739,0.000007414946,0.0007124553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005965155,"threshold_uncertainty_score":0.001509368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006885511713429042,"score_gpt":0.2100692825779178,"score_spread":0.2031837708644888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}