{"id":"W4214906120","doi":"10.1016/j.molcel.2022.02.022","title":"The case for brakes: Why restrain the size of Bax and Bak pores in outer mitochondrial membranes?","year":2022,"lang":"en","type":"letter","venue":"Molecular Cell","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Biology; Mitochondrion; Cell biology; Apoptosis; Mitochondrial DNA; Membrane; Bacterial outer membrane; Biophysics; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004705136,0.000936724,0.001812824,0.0004667359,0.002612664,0.00340184,0.002239131,0.04155157,0.004613135],"category_scores_gemma":[0.01948503,0.0006379268,0.001336324,0.0003108685,0.005975946,0.007758758,0.002184012,0.05068377,0.004549766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003450328,"about_ca_system_score_gemma":0.001916569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001348754,"about_ca_topic_score_gemma":0.00161169,"domain_scores_codex":[0.9976763,0.0005480734,0.000259686,0.0004465021,0.0007426261,0.0003268254],"domain_scores_gemma":[0.9917299,0.005205014,0.0004675506,0.0004539216,0.0009789983,0.001164578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0004593942,0.00009588298,0.0006131062,0.0001664596,0.00007638401,0.003184439,0.0002381302,0.0002056243,0.002116753,0.01603023,0.9536084,0.02320518],"study_design_scores_gemma":[0.0006819127,0.0002638361,0.001265348,0.0002375484,0.00006741787,0.003747366,0.0007192031,0.001208097,0.003013886,0.1158926,0.8726935,0.0002092958],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0007658695,0.003932477,0.0003414468,0.9773441,0.01656883,0.00000839627,0.0000370083,0.00005394596,0.0009479131],"genre_scores_gemma":[0.01354096,0.004084911,0.0007644632,0.9255319,0.05161154,0.00005656022,0.0000309756,0.00004855166,0.004330188],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.04155157,"threshold_uncertainty_score":0.02503407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005220292780862683,"score_gpt":0.2096909439484436,"score_spread":0.2044706511675809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}