{"id":"W4214919916","doi":"10.1016/j.ymeth.2022.03.002","title":"Structure-function analysis of DEAD-box helicase DDX43","year":2022,"lang":"en","type":"article","venue":"Methods","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Helicase; RNA Helicase A; Processivity; DEAD box; Biology; Cell biology; Chromatin immunoprecipitation; Electrophoretic mobility shift assay; Immunoprecipitation; AAA proteins; Molecular biology; Chemistry; DNA; Biochemistry; Gene; ATPase; RNA; Transcription factor; DNA replication; Gene expression; Promoter; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000682961,0.00006427675,0.0001466578,0.0001449649,0.0001013373,0.000006624303,0.0001338551,0.00003700598,0.0004102917],"category_scores_gemma":[0.0001297419,0.00006060976,0.0001390876,0.0005017885,0.00002641878,0.000001181186,0.0001645918,0.00009508546,4.462416e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001359019,"about_ca_system_score_gemma":0.00003431614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007689396,"about_ca_topic_score_gemma":0.00002553835,"domain_scores_codex":[0.9989069,0.0004588853,0.0001362088,0.0002030573,0.0001482846,0.0001466817],"domain_scores_gemma":[0.9995185,0.00002900647,0.0000561044,0.0002982173,0.00004561661,0.00005256798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009289465,0.00001796445,0.00191078,0.000004890785,0.000366485,0.000001465554,0.00001449778,0.001590452,0.9639235,0.00006782674,0.0002217675,0.03178746],"study_design_scores_gemma":[0.0002692728,0.0004510477,0.00755044,7.474671e-7,0.0003032795,0.000006313883,0.0001396658,0.003833394,0.9471027,0.0001882765,0.04002995,0.0001248964],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8554131,0.0004227415,0.1436871,0.00003760706,0.00006500629,0.00005805578,0.00004160193,0.000004566622,0.0002702489],"genre_scores_gemma":[0.9429979,0.00001623686,0.05519221,0.00016682,0.00005031843,0.00001660906,0.0001621432,0.000009875468,0.00138783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08849491,"threshold_uncertainty_score":0.4492406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02189030755057999,"score_gpt":0.3811296424520196,"score_spread":0.3592393349014397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}