{"id":"W4214923702","doi":"10.1101/2022.03.02.482658","title":"Critical role of PCYT2 in muscle health and aging","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Guelph","funders":"National Institutes of Health; Science for Life Laboratory; Agence Nationale de la Recherche; Austrian Science Fund; Karolinska Institutet; European Commission; Österreichische Forschungsförderungsgesellschaft; Österreichischen Akademie der Wissenschaften; Wellcome Trust","keywords":"Muscle weakness; Exercise intolerance; Skeletal muscle; Biology; Myocyte; Dysferlin; Failure to thrive; Weakness; Muscular dystrophy; Sarcopenia; Cell biology; Internal medicine; Medicine; Endocrinology; Heart failure; Genetics; Anatomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016879,0.0004331269,0.0002214913,0.0002179551,0.0002533114,0.0004018505,0.0002046395,0.0005554164,0.001158638],"category_scores_gemma":[0.0001348276,0.00009520052,0.0001722303,0.0001496979,0.0002850338,0.0003162466,0.0004319373,0.0005293238,0.0004135589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003457832,"about_ca_system_score_gemma":0.0002579429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004935401,"about_ca_topic_score_gemma":0.0003802583,"domain_scores_codex":[0.9999138,0.00001136026,0.000007668208,0.00003029421,0.00002114492,0.00001585457],"domain_scores_gemma":[0.9998837,0.000009224645,0.00003426571,0.000007222507,0.00002861252,0.0000370158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004836053,0.00002451525,0.001638072,0.0001641947,0.000021425,0.0005736578,0.0000249707,0.000151355,0.9888114,0.0008837767,0.0007993007,0.006423735],"study_design_scores_gemma":[0.000114511,0.0007256233,0.05939003,0.0001206957,0.0001398784,0.0052494,0.0001674975,0.003908562,0.8752185,0.002125037,0.05280653,0.00003363334],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8910823,0.08011679,0.01555384,0.002633088,0.0008410348,0.00007946102,0.002075641,0.0004444383,0.007173464],"genre_scores_gemma":[0.9808287,0.008445744,0.002710649,0.0003944537,0.0001326421,0.00004407293,0.00094938,0.00002860996,0.00646583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001158638,"threshold_uncertainty_score":0.003875971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01337662183326463,"score_gpt":0.2747014664946125,"score_spread":0.2613248446613479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}