{"id":"W4214928936","doi":"10.1016/j.ebiom.2022.103916","title":"Fatty acid metabolism and drug resistance to EZH2 inhibition","year":2022,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Ovarian Cancer Canada; Cancer Research Society","keywords":"PRC2; EZH2; Histone H3; Methyltransferase; Epigenetics; Cancer research; Histone methyltransferase; Chromatin; Biology; Histone; Gene silencing; Genetics; Methylation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003099098,0.00008511485,0.0001000199,0.00006901852,0.0001415725,0.000007647068,0.00005873842,0.00002674645,0.00005038029],"category_scores_gemma":[0.00004524318,0.00008259881,0.00002188613,0.0001589014,0.00004000552,0.000001605269,0.0001458375,0.00006439663,0.000003185803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001180829,"about_ca_system_score_gemma":0.00001900527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001152237,"about_ca_topic_score_gemma":0.00002831837,"domain_scores_codex":[0.999251,0.00005708256,0.0001384529,0.0002514858,0.000168581,0.0001333606],"domain_scores_gemma":[0.9996367,0.000006058151,0.0000432577,0.0001887398,0.00003559058,0.00008972179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005620394,0.00001998464,0.0002914222,0.00000812957,0.000009570401,0.000003111658,0.0001684703,0.000008164884,0.9915963,0.0001185054,0.005338079,0.002382105],"study_design_scores_gemma":[0.0004722065,0.0001070123,0.006067167,0.000005296917,0.00001257416,0.000002304904,0.0001043972,0.000004251669,0.542441,0.0003625827,0.4503169,0.0001043978],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983355,0.008234378,0.003323138,0.003518101,0.000258926,0.0001721111,0.00003221447,0.0000110471,0.001095121],"genre_scores_gemma":[0.9950851,0.0001824858,0.001537828,0.0008006073,0.0002775209,0.00004074908,0.0002043377,0.00001316937,0.001858182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4491553,"threshold_uncertainty_score":0.3368281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006623717357026858,"score_gpt":0.2422054780498975,"score_spread":0.2355817606928707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}