{"id":"W4214928936","doi":"10.1016/j.ebiom.2022.103916","title":"Fatty acid metabolism and drug resistance to EZH2 inhibition","year":2022,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Ovarian Cancer Canada; Cancer Research Society","keywords":"PRC2; EZH2; Histone H3; Methyltransferase; Epigenetics; Cancer research; Histone methyltransferase; Chromatin; Biology; Histone; Gene silencing; Genetics; Methylation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002829447,0.0002081032,0.0004546055,0.0005598392,0.0001380611,0.0004398453,0.000211809,0.0002709629,0.005863793],"category_scores_gemma":[0.0004606906,0.0000838093,0.0003097727,0.0007125441,0.0001228707,0.0002454631,0.0002052757,0.0004929698,0.0009348757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006094232,"about_ca_system_score_gemma":0.0002440934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005891282,"about_ca_topic_score_gemma":0.001208645,"domain_scores_codex":[0.9998587,0.00002171956,0.00001245932,0.0000274937,0.00004975214,0.00002982299],"domain_scores_gemma":[0.9998391,0.00003342091,0.00004638535,0.00001594268,0.00003434682,0.00003088657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005092989,0.0005818895,0.03271826,0.001309161,0.000763104,0.00379222,0.0002237416,0.002059707,0.4675828,0.002552376,0.01584801,0.4674757],"study_design_scores_gemma":[0.00129714,0.00688475,0.149308,0.0003490061,0.00126526,0.02072509,0.0004489377,0.006455274,0.416902,0.002981853,0.3932803,0.0001024143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8569816,0.1063057,0.00200539,0.003523206,0.0002937685,0.0001409826,0.002120648,0.0004689556,0.02815975],"genre_scores_gemma":[0.9680744,0.01864731,0.0006394039,0.0005910436,0.00005108695,0.00004985054,0.002131027,0.00003946215,0.009776406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005863793,"threshold_uncertainty_score":0.01961631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006623717357026858,"score_gpt":0.2422054780498975,"score_spread":0.2355817606928707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}