{"id":"W4214929818","doi":"10.1080/14737159.2022.2049248","title":"Early predictive value of circulating biomarkers for sorafenib in advanced hepatocellular carcinoma","year":2022,"lang":"en","type":"review","venue":"Expert Review of Molecular Diagnostics","topic":"Hepatocellular Carcinoma Treatment and Prognosis","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Sorafenib; Hepatocellular carcinoma; Medicine; Oncology; Liquid biopsy; Internal medicine; Biomarker; Bevacizumab; Carcinoma; Liver biopsy; Lenvatinib; Biopsy; Cancer; Chemotherapy","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00161933,0.0003364163,0.001161349,0.001478529,0.00008353873,0.0007502271,0.0002901055,0.0004705606,0.002012848],"category_scores_gemma":[0.007462928,0.0001201453,0.001226751,0.001385436,0.0002037102,0.0005843413,0.0002232803,0.0005493017,0.0001865469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003695699,"about_ca_system_score_gemma":0.0007059255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009772042,"about_ca_topic_score_gemma":0.00142558,"domain_scores_codex":[0.9992298,0.0003147904,0.0001454361,0.000102654,0.0001752923,0.00003196393],"domain_scores_gemma":[0.9952702,0.003092803,0.001012473,0.00004031691,0.0005238986,0.00006019923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003747458,0.00008508686,0.06736057,0.107038,0.005272548,0.0006247789,0.0001771461,0.00138838,0.002861522,0.001006829,0.0097616,0.800676],"study_design_scores_gemma":[0.001790039,0.004409237,0.4816835,0.1302505,0.0506874,0.01099328,0.00093203,0.006046811,0.01118008,0.006326928,0.2952815,0.0004187596],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01028728,0.9873102,0.0003688634,0.0006513855,0.0001639962,0.00002691839,0.0004283795,0.000007217093,0.0007556636],"genre_scores_gemma":[0.3079559,0.6870029,0.001920957,0.0008043539,0.0007141243,0.00008711205,0.0009788155,0.000007326366,0.0005283913],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002012848,"threshold_uncertainty_score":0.008563936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05892041284594619,"score_gpt":0.3287539665386544,"score_spread":0.2698335536927082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}