{"id":"W4214940159","doi":"10.1038/s41591-021-01659-1","title":"The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial","year":2022,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":895,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Duke Clinical Research Institute; Max Rady College of Medicine, University of Manitoba; Akershus Universitetssykehus; Sahlgrenska Universitetssjukhuset; Capital Medical University; Rijksuniversiteit Groningen; Institut National de la Santé et de la Recherche Médicale; Göteborgs Universitet; Boehringer Ingelheim; National University of Singapore; School of Medicine, University of Missouri; Universität Heidelberg; Masarykova Univerzita; Universidade do Porto; Uniwersytet Łódzki; Vanderbilt University Medical Center; KU Leuven; University of Missouri; University of Missouri-Kansas City; Saint Luke's Health System; Université de Lorraine; Vanderbilt University; Universitair Medisch Centrum Groningen; Eli Lilly and Company; National University Health System; University of New South Wales; U.S. Department of Veterans Affairs","keywords":"Empagliflozin; Medicine; Heart failure; Ejection fraction; Clinical endpoint; Placebo; Internal medicine; Randomized controlled trial; Acute decompensated heart failure; Cardiology; Hazard ratio; Confidence interval; Randomization; Clinical trial; Diabetes mellitus; Type 2 diabetes; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002872229,0.001043106,0.002164982,0.0002882174,0.0003406113,0.0008992223,0.0005907033,0.001389577,0.005259463],"category_scores_gemma":[0.002616829,0.0004058703,0.001731966,0.0003631943,0.0006794497,0.0008067625,0.0004849376,0.002010689,0.0005493208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005419357,"about_ca_system_score_gemma":0.0008376405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009785038,"about_ca_topic_score_gemma":0.002437537,"domain_scores_codex":[0.999225,0.0005040474,0.00005352966,0.0001015105,0.0000498468,0.00006618167],"domain_scores_gemma":[0.9990035,0.0003152574,0.0002759994,0.00009246975,0.00007245923,0.0002403357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9768656,0.002512842,0.001158601,0.0008159534,0.001898169,0.00002738758,0.0000379842,0.0002795953,0.0009508058,0.0001121532,0.001215384,0.01412554],"study_design_scores_gemma":[0.9820042,0.01339016,0.002278396,0.00006438752,0.001053078,0.00002046656,0.00001392178,0.0004621694,0.0001472218,0.00009022365,0.0004678729,0.000007838142],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9783237,0.01049795,0.001013414,0.001827746,0.0009209256,0.002881709,0.001513907,0.0001490627,0.002871637],"genre_scores_gemma":[0.9826695,0.004421143,0.00200327,0.002208433,0.0006235105,0.004023823,0.001527849,0.0000259081,0.002496542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005259463,"threshold_uncertainty_score":0.01759464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004595019715807455,"score_gpt":0.2794361358209175,"score_spread":0.2748411161051101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}