{"id":"W4214941797","doi":"10.1186/s40478-022-01328-5","title":"Circular RNA detection identifies circPSEN1 alterations in brain specific to autosomal dominant Alzheimer's disease","year":2022,"lang":"en","type":"article","venue":"Acta Neuropathologica Communications","topic":"Circular RNAs in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Instituto de Salud Carlos III; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Institutes of Health; Alzheimer's Drug Discovery Foundation; Deutsches Zentrum für Neurodegenerative Erkrankungen; National Institute on Aging; Alzheimer's Association; Hope Center for Neurological Disorders; Japan Agency for Medical Research and Development; Fondation Brain Canada; BrightFocus Foundation; Foundation for the National Institutes of Health; Korea Health Industry Development Institute; U.S. Department of Defense","keywords":"Neurology; Disease; Neuroscience; Alzheimer's disease; Medicine; Biology; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003648042,0.0002038063,0.0001670352,0.0001984708,0.0009135199,0.00008460269,0.00136878,0.00004958647,0.00008571516],"category_scores_gemma":[0.0006144065,0.0002385011,0.0001563914,0.0004805063,0.000166998,0.00001629471,0.00185235,0.000310819,0.00002810276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005582412,"about_ca_system_score_gemma":0.00008251737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001562114,"about_ca_topic_score_gemma":0.00005656769,"domain_scores_codex":[0.9974234,0.00108005,0.0003821726,0.0005815586,0.0002256027,0.0003072715],"domain_scores_gemma":[0.9968257,0.0001093529,0.0001220103,0.002699124,0.0000667472,0.0001770974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00007719104,0.0004520579,0.002017749,0.000003504944,0.00001736183,0.00005201307,0.0001311938,0.0008606434,0.9937656,0.0002117376,0.001086568,0.001324372],"study_design_scores_gemma":[0.001407163,0.000671608,0.608398,0.0000288084,0.000174701,0.0003575933,0.0008417302,0.001155992,0.06894086,0.0008774629,0.3158246,0.001321502],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898032,0.002782189,0.000761201,0.004794379,0.0002575477,0.0007308837,0.0001628228,0.00005084976,0.0006569143],"genre_scores_gemma":[0.996673,0.000319953,0.0002591637,0.001352755,0.00006664587,0.0008119618,0.0003921875,0.00003996231,0.0000843807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9248248,"threshold_uncertainty_score":0.9725795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03091991213758499,"score_gpt":0.2812936999802176,"score_spread":0.2503737878426326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}