{"id":"W4214941797","doi":"10.1186/s40478-022-01328-5","title":"Circular RNA detection identifies circPSEN1 alterations in brain specific to autosomal dominant Alzheimer's disease","year":2022,"lang":"en","type":"article","venue":"Acta Neuropathologica Communications","topic":"Circular RNAs in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Instituto de Salud Carlos III; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Institutes of Health; Alzheimer's Drug Discovery Foundation; Deutsches Zentrum für Neurodegenerative Erkrankungen; National Institute on Aging; Alzheimer's Association; Hope Center for Neurological Disorders; Japan Agency for Medical Research and Development; Fondation Brain Canada; BrightFocus Foundation; Foundation for the National Institutes of Health; Korea Health Industry Development Institute; U.S. Department of Defense","keywords":"Neurology; Disease; Neuroscience; Alzheimer's disease; Medicine; Biology; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004319369,0.0005058301,0.0003917319,0.00113172,0.0004539302,0.0006061086,0.0002030361,0.0003916261,0.00453067],"category_scores_gemma":[0.0009016151,0.0002365362,0.0004049713,0.0004979814,0.0003047196,0.0002191186,0.0004050498,0.0004541752,0.001121184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002630379,"about_ca_system_score_gemma":0.0002209505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001194176,"about_ca_topic_score_gemma":0.002749226,"domain_scores_codex":[0.999655,0.00001905714,0.00001831139,0.0001917454,0.00007470329,0.00004109345],"domain_scores_gemma":[0.9995927,0.000138551,0.0001072804,0.00004030577,0.00007857993,0.00004268138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001365543,0.00005495992,0.06263494,0.0007411707,0.0002577156,0.0005580577,0.0002732491,0.0006975578,0.9033637,0.0005026889,0.002993444,0.02655706],"study_design_scores_gemma":[0.00009413706,0.0004732812,0.6300152,0.0002085503,0.0006468597,0.004112018,0.0004386523,0.01033158,0.3273257,0.002710558,0.02354714,0.00009624905],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9586434,0.003911967,0.0145822,0.000204556,0.0001294555,0.0000575449,0.01845153,0.000994035,0.00302529],"genre_scores_gemma":[0.9513681,0.001288533,0.02341915,0.0003601258,0.0000668488,0.0001518095,0.01930347,0.0006198352,0.003422259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00453067,"threshold_uncertainty_score":0.01515657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03091991213758499,"score_gpt":0.2812936999802176,"score_spread":0.2503737878426326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}