{"id":"W4214950345","doi":"10.1038/s41587-022-01219-z","title":"Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells","year":2022,"lang":"en","type":"article","venue":"Nature Biotechnology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":414,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biocenter Finland; Helsinki Institute of Life Science, Helsingin Yliopisto; Innovative Medicines Initiative; Vetenskapsrådet; Barndiabetesfonden; European Federation of Pharmaceutical Industries and Associations; Novo Nordisk; Diabetes Wellness Suomi Säätiö; Leona M. and Harry B. Helmsley Charitable Trust; Novo Nordisk Fonden; Academy of Finland; Stiftelsen Familjen Ernfors Fond; University of Alberta; Sigrid Juséliuksen Säätiö","keywords":"Islet; Pancreatic islets; Biology; Cell biology; Transplantation; Transcriptome; Induced pluripotent stem cell; Stem cell; Insulin; Exocytosis; Secretion; Internal medicine; Endocrinology; Embryonic stem cell; Gene; Biochemistry; Gene expression; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002211969,0.0001589019,0.0001339797,0.0001407801,0.00007538568,0.0004640248,0.00008546418,0.0001109256,0.0007140004],"category_scores_gemma":[0.0002121872,0.00007773125,0.0001626534,0.0001450026,0.000152367,0.0001618687,0.0001600364,0.0003938984,0.0002675104],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001069017,"about_ca_system_score_gemma":0.0001639514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001424179,"about_ca_topic_score_gemma":0.0001862311,"domain_scores_codex":[0.9999018,0.00001291405,0.0000104427,0.00002860262,0.00003455132,0.00001164467],"domain_scores_gemma":[0.9999146,0.00001984851,0.0000159999,0.00001220733,0.00001920497,0.00001814539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007139165,0.00001190066,0.0004748308,0.00002705507,0.000003259111,0.00002738553,0.00002878369,0.0002090073,0.9954957,0.00007364121,0.00004597129,0.003531164],"study_design_scores_gemma":[0.000005974177,0.0002258754,0.009545048,0.0000129861,0.00001895333,0.0001295044,0.00005896105,0.001007598,0.9832323,0.0001209548,0.005635167,0.00000649226],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9742543,0.002830832,0.01835047,0.00008406633,0.00005145384,0.00008162921,0.00135375,0.0001477013,0.002845726],"genre_scores_gemma":[0.9820296,0.001913136,0.01072312,0.0001119138,0.00002235201,0.00009024784,0.002703565,0.00009778203,0.002308355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007140004,"threshold_uncertainty_score":0.002388597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01293048939439768,"score_gpt":0.230955692279299,"score_spread":0.2180252028849013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}