{"id":"W4214951735","doi":"10.3389/fphar.2022.838782","title":"Formation, Signaling and Occurrence of Specialized Pro-Resolving Lipid Mediators—What is the Evidence so far?","year":2022,"lang":"en","type":"review","venue":"Frontiers in Pharmacology","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":184,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Vetenskapsrådet; Wellcome Trust; National Heart, Lung, and Blood Institute; Fonds De La Recherche Scientifique - FNRS; Deutsche Forschungsgemeinschaft; American Heart Association","keywords":"Arachidonic acid; Lipid signaling; Docosahexaenoic acid; Eicosapentaenoic acid; Polyunsaturated fatty acid; Receptor; CYP2C8; Lipoxygenase; Chemistry; Context (archaeology); Biochemistry; Signal transduction; Fatty acid; G protein-coupled receptor; Cell biology; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002494144,0.0008727059,0.001900951,0.00180593,0.0007794456,0.004697819,0.001595478,0.003237886,0.003509508],"category_scores_gemma":[0.004123702,0.0005182316,0.0009305382,0.001969753,0.002667419,0.005450691,0.001561782,0.00241746,0.002368178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000723609,"about_ca_system_score_gemma":0.001979886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001123446,"about_ca_topic_score_gemma":0.0006811227,"domain_scores_codex":[0.9986079,0.0002228719,0.0002536674,0.0005137165,0.0002223543,0.000179476],"domain_scores_gemma":[0.9938094,0.002859649,0.001280414,0.0004222596,0.001317622,0.0003106337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.003587027,0.0007323195,0.02962216,0.08971019,0.001218612,0.003520035,0.001282727,0.001223632,0.101171,0.02234664,0.01525195,0.7303337],"study_design_scores_gemma":[0.0001437796,0.002789395,0.06237581,0.01810679,0.002768709,0.01752181,0.008740947,0.002498561,0.10139,0.04724862,0.7359033,0.0005123427],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01531608,0.9753749,0.002493742,0.003408653,0.0005939382,0.00002805213,0.0003813693,0.00004399789,0.002359272],"genre_scores_gemma":[0.06986941,0.9201363,0.002453065,0.002670521,0.002751746,0.00005964086,0.0008854333,0.00002122445,0.001152619],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004697819,"threshold_uncertainty_score":0.01319045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0509032889748204,"score_gpt":0.3506103870715128,"score_spread":0.2997070980966924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}