{"id":"W4220653200","doi":"10.1038/s41386-022-01301-9","title":"Repeated lysergic acid diethylamide (LSD) reverses stress-induced anxiety-like behavior, cortical synaptogenesis deficits and serotonergic neurotransmission decline","year":2022,"lang":"en","type":"article","venue":"Neuropsychopharmacology","topic":"Psychedelics and Drug Studies","field":"Psychology","cited_by":89,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Serotonergic; Lysergic acid diethylamide; Anxiolytic; Serotonin; Dorsal raphe nucleus; Agonist; Antidepressant; Internal medicine; Neurotransmission; Endocrinology; Psychology; Neuroscience; Pharmacology; Raphe nuclei; Hippocampus; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001221988,0.0004596843,0.0004582685,0.0003356594,0.0002374795,0.0003109723,0.000315991,0.0003539012,0.00258513],"category_scores_gemma":[0.0003015751,0.0002255602,0.0002802257,0.0001548392,0.0006005144,0.0003914034,0.0001912239,0.001073417,0.0003928669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000353431,"about_ca_system_score_gemma":0.0006281222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002126395,"about_ca_topic_score_gemma":0.005152943,"domain_scores_codex":[0.9999161,0.00001440684,0.000007862374,0.00001540018,0.00001489227,0.00003131844],"domain_scores_gemma":[0.9996409,0.00003682126,0.0001136808,0.00005822706,0.00002224883,0.0001279738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01859448,0.001919163,0.001351956,0.0001032575,0.00009059419,0.0002993373,0.0000966498,0.0001257876,0.9670467,0.0002480321,0.0002432697,0.009880785],"study_design_scores_gemma":[0.001333329,0.03360034,0.05155592,0.0000402665,0.0002007382,0.001022166,0.0005436289,0.001488884,0.9082683,0.0003417149,0.001557274,0.00004750099],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985591,0.0002735147,0.0002569043,0.00006833546,0.00002993514,0.00001559321,0.0001891687,0.00006136655,0.0005463202],"genre_scores_gemma":[0.9968824,0.0003978437,0.0002540588,0.00003942495,0.00001455076,0.00001899159,0.0002666427,0.00001025742,0.002115759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00258513,"threshold_uncertainty_score":0.008648157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03364226628108727,"score_gpt":0.3370747207459024,"score_spread":0.3034324544648151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}