{"id":"W4220654270","doi":"10.1101/2022.03.07.483298","title":"Proteomic Profiling of Hypoplastic Lungs Suggests an Underlying Inflammatory Response in the Pathogenesis of Abnormal Lung Development in Congenital Diaphragmatic Hernia","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Congenital Diaphragmatic Hernia Studies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"","keywords":"Congenital diaphragmatic hernia; Nitrofen; Lung; Pathogenesis; Pathology; Medicine; Pulmonary hypoplasia; Fetus; Diaphragmatic hernia; Biology; Hernia; Internal medicine; Pregnancy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001499795,0.0002040132,0.0001803723,0.0004169273,0.0001495591,0.000200491,0.0001040224,0.0002300165,0.0006126945],"category_scores_gemma":[0.00008836474,0.0001241378,0.0001960678,0.0002096169,0.0001681287,0.0001526581,0.0001744582,0.0002561539,0.0001285536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001322124,"about_ca_system_score_gemma":0.000122499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003204874,"about_ca_topic_score_gemma":0.0004859737,"domain_scores_codex":[0.999923,0.00001101386,0.000006556862,0.00001799783,0.00002538597,0.00001610055],"domain_scores_gemma":[0.9999213,0.00001212457,0.00002693179,0.000005614987,0.00001424032,0.00001978312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009041528,0.000006665053,0.002584058,0.00003664004,0.000006124023,0.00008183638,0.00001187209,0.00001806184,0.9964671,0.00001390448,0.00001488258,0.0006684029],"study_design_scores_gemma":[0.00001194699,0.0003500092,0.4053004,0.00002212177,0.00005540814,0.002889683,0.0002532965,0.001485764,0.5874864,0.0001349259,0.001998884,0.0000111056],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961315,0.001636608,0.001298001,0.00005727425,0.000009830787,0.0000108099,0.0005605334,0.00002013382,0.0002752871],"genre_scores_gemma":[0.99443,0.001385421,0.002433344,0.00007130332,0.000006633266,0.0000197033,0.0009701293,0.000006509119,0.0006769868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006126945,"threshold_uncertainty_score":0.002049685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0210812023040702,"score_gpt":0.2571776569173523,"score_spread":0.2360964546132821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}