{"id":"W4220656584","doi":"10.1038/s42003-022-03231-0","title":"Transcriptome-wide association study reveals increased neuronal FLT3 expression is associated with Tourette’s syndrome","year":2022,"lang":"en","type":"article","venue":"Communications Biology","topic":"Obsessive-Compulsive Spectrum Disorders","field":"Psychology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Tourette syndrome; Transcriptome; Association (psychology); Tics; Biology; Neuroscience; Genome-wide association study; Genetics; Medicine; Gene expression; Psychology; Gene; Psychiatry; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009140759,0.0002766693,0.0004958632,0.0002993581,0.00108771,0.00002908861,0.001840523,0.0001679159,0.003426045],"category_scores_gemma":[0.0004902252,0.0002765992,0.0001213394,0.0008253374,0.000183388,0.00009196629,0.0005496405,0.0009950154,0.0001008094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005126187,"about_ca_system_score_gemma":0.00008953474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000358954,"about_ca_topic_score_gemma":0.0002177234,"domain_scores_codex":[0.9933052,0.004773383,0.0005350206,0.0005660995,0.0002969701,0.0005233285],"domain_scores_gemma":[0.9949397,0.002040996,0.0006033361,0.002161425,0.0001576216,0.0000968818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001293011,0.002602287,0.9745411,0.000001889715,0.0004903118,0.000018137,0.004362243,0.000009442566,0.00232004,0.001197566,0.0141821,0.0001456016],"study_design_scores_gemma":[0.003315956,0.001537451,0.97887,0.00001361276,0.0001597867,0.00001806496,0.004329391,0.00002677613,0.00002720148,0.001311591,0.009995583,0.0003945876],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828412,0.0006074926,0.00007217211,0.009282321,0.0003596027,0.001071637,0.0003254854,0.0002214251,0.00521866],"genre_scores_gemma":[0.9939219,0.00001769999,0.0001548041,0.002752741,0.00001637685,0.001015291,0.0007469999,0.00005427365,0.001319882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01108073,"threshold_uncertainty_score":0.9999686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02444844581978151,"score_gpt":0.3066238265140854,"score_spread":0.2821753806943039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}