{"id":"W4220657604","doi":"10.34172/bi.2022.23896","title":"Recent advances in cancer immunotherapy: Modulation of tumor microenvironment by Toll-like receptor ligands","year":2022,"lang":"en","type":"review","venue":"Bioimpacts","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Immunotherapy; Medicine; Tumor microenvironment; Cancer immunotherapy; Immunosuppression; Cancer; Toll-like receptor; Immunology; Cancer research; Immune system; Internal medicine; Innate immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004773132,0.0006198045,0.001815637,0.0003887379,0.0001279824,0.000015689,0.0005286296,0.0003870291,0.005417122],"category_scores_gemma":[0.00005056984,0.0005244745,0.0004072452,0.0004482762,0.0002004858,0.0001844879,0.0001167411,0.0006364901,0.0000762866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007010503,"about_ca_system_score_gemma":0.0003930538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000114694,"about_ca_topic_score_gemma":0.00001041533,"domain_scores_codex":[0.9969556,0.0006534501,0.001141802,0.0005367526,0.0001063009,0.0006060604],"domain_scores_gemma":[0.9981112,0.0002700599,0.0009656735,0.0006066422,0.0000197647,0.00002659965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005278602,0.0003836833,0.00001594518,0.0009093388,0.0003586814,0.000002229833,0.0001986587,0.000004185281,0.03885772,0.000002553702,0.003571593,0.9551675],"study_design_scores_gemma":[0.001127713,0.000421322,0.00005123214,0.00228354,0.00009691658,0.00003386705,0.00005779702,1.9278e-7,0.005950551,0.000002818045,0.9894742,0.000499823],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001655425,0.9948356,0.000002864371,0.00004480229,0.001721109,0.001034484,0.0005918679,0.00005488329,0.00005902016],"genre_scores_gemma":[0.0001445012,0.9966502,0.00001281867,0.0001284092,0.00002541784,0.0003604362,0.0009546473,0.0001312951,0.00159225],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9859026,"threshold_uncertainty_score":0.9997207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02667474397234423,"score_gpt":0.3033155948236597,"score_spread":0.2766408508513154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}