{"id":"W4220661883","doi":"10.1016/j.celrep.2022.110573","title":"Genome-wide analysis of haploinsufficiency in human embryonic stem cells","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Azrieli Foundation; Israel Science Foundation; Rosetrees Trust","keywords":"Haploinsufficiency; Biology; Embryonic stem cell; Genetics; Phenotype; Gene; Telomere; Cell biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000721999,0.0001284466,0.000280126,0.0003970536,0.0001140539,0.00001057513,0.0002649315,0.00006260467,0.0002181649],"category_scores_gemma":[0.00001111123,0.0001415759,0.0002171669,0.0008679692,0.00005706893,0.000002255826,0.0004624632,0.00015877,0.00000237104],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007056504,"about_ca_system_score_gemma":0.0001469705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006046556,"about_ca_topic_score_gemma":0.00004163356,"domain_scores_codex":[0.9980859,0.0001341646,0.00049484,0.000535232,0.0004192274,0.0003306713],"domain_scores_gemma":[0.9988161,0.00001457965,0.0002803847,0.000750002,0.00005991393,0.00007899561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001166473,0.0002711057,0.03770908,0.0000278396,0.00009141425,0.0003079636,0.00007099907,0.02116731,0.940127,0.00000147168,0.0001708394,0.00004329262],"study_design_scores_gemma":[0.0002481969,0.0003300956,0.0304898,0.000002821174,0.0001294468,0.00002225654,0.000273345,0.0003144974,0.9462283,0.00001140261,0.0216953,0.0002545483],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924913,0.0009427717,0.00008865725,0.00001374401,0.00009369447,0.000223304,0.00001317216,0.000007179194,0.00612618],"genre_scores_gemma":[0.9911215,0.0000551057,0.00001848886,0.00002703418,0.00001568732,0.00003603238,0.0001482682,0.00001982217,0.008558116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02152446,"threshold_uncertainty_score":0.5773299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01240729883448109,"score_gpt":0.2511530438275764,"score_spread":0.2387457449930953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}