{"id":"W4220661883","doi":"10.1016/j.celrep.2022.110573","title":"Genome-wide analysis of haploinsufficiency in human embryonic stem cells","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Azrieli Foundation; Israel Science Foundation; Rosetrees Trust","keywords":"Haploinsufficiency; Biology; Embryonic stem cell; Genetics; Phenotype; Gene; Telomere; Cell biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000174993,0.0001557169,0.0002249271,0.0006329127,0.000167976,0.0002127317,0.00009176985,0.0002161227,0.0009126889],"category_scores_gemma":[0.0001785501,0.0001115284,0.0001922451,0.0005130221,0.0001258844,0.00005193766,0.0001928048,0.0002410829,0.0001386141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007832286,"about_ca_system_score_gemma":0.00008390334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004833708,"about_ca_topic_score_gemma":0.0008921114,"domain_scores_codex":[0.9998806,0.00001455552,0.00001151006,0.00004743594,0.00003288613,0.00001300558],"domain_scores_gemma":[0.9998758,0.00004506031,0.00003118077,0.00001417298,0.00001423286,0.00001951455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000132947,0.00001187904,0.02103956,0.00005909593,0.00007798454,0.000227415,0.00004635888,0.0001524432,0.9735286,0.0001058437,0.0001181488,0.004499653],"study_design_scores_gemma":[0.00001808811,0.0001694784,0.7810707,0.00001334786,0.0001875711,0.002087059,0.00009802492,0.001219428,0.2098847,0.0001671577,0.005070737,0.00001370653],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946649,0.000973866,0.001528411,0.00002997653,0.000004811093,0.00001624653,0.002179804,0.00003305397,0.0005687736],"genre_scores_gemma":[0.9926122,0.0005400885,0.001626105,0.00005419338,0.000002918052,0.00003129445,0.004497342,0.00001972922,0.0006160171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009126889,"threshold_uncertainty_score":0.003053248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01240729883448109,"score_gpt":0.2511530438275764,"score_spread":0.2387457449930953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}