{"id":"W4220663751","doi":"10.1007/s40261-022-01129-7","title":"Multiple Sclerosis Relapses Following Cessation of Fingolimod","year":2022,"lang":"en","type":"article","venue":"Clinical Drug Investigation","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre intégré de santé et de services sociaux de Chaudière-Appalaches","funders":"National Health and Medical Research Council; Grifols; Multiple Sclerosis Society; Multiple Sclerosis International Federation; Acorda Therapeutics; Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques; Teva Pharmaceutical Industries; Biogen; Celgene; Fondazione Italiana Sclerosi Multipla; Sanofi Genzyme; University of Melbourne; Sanofi","keywords":"Fingolimod; Medicine; Smoking cessation; Multiple sclerosis; Internal medicine; Pharmacotherapy; Disease; Physical therapy; Psychiatry; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.002140638,0.0001269302,0.0004283301,0.0001534074,0.0003352918,0.00001207723,0.0001558179,0.0000592358,0.0001059611],"category_scores_gemma":[0.00869269,0.0001231056,0.0003060774,0.0004986235,0.0002914659,0.000138063,0.0002877398,0.0004999117,0.00001518174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001232948,"about_ca_system_score_gemma":0.0001846481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002012637,"about_ca_topic_score_gemma":0.0000237083,"domain_scores_codex":[0.9971947,0.000505005,0.0008811899,0.0003700933,0.0008143812,0.0002346437],"domain_scores_gemma":[0.997415,0.001560982,0.0002995412,0.0003684134,0.0001586773,0.0001973836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001774631,0.0003268123,0.953728,0.0001153938,0.0001597454,0.000003796801,0.001154931,0.0003353763,0.02378215,0.0001522729,0.008366724,0.01169735],"study_design_scores_gemma":[0.003141101,0.0003436373,0.977371,0.0001831071,0.00009950206,0.000001222958,0.0008369092,0.007851139,0.007657183,0.0005349904,0.001836864,0.0001433578],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949943,0.0001868787,0.00007114612,0.003116777,0.0004274074,0.0005531753,0.00002583896,0.00008341471,0.0005411006],"genre_scores_gemma":[0.9961937,0.0001448436,0.002316217,0.0005698701,0.0001578031,0.0001569753,0.0001263999,0.00002396038,0.0003102412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02364299,"threshold_uncertainty_score":0.9996575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1972093104389497,"score_gpt":0.3747379330857507,"score_spread":0.177528622646801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}