{"id":"W4220664559","doi":"10.1200/jco.21.01612","title":"Sorafenib in Combination With Standard Chemotherapy for Children With High Allelic Ratio <i>FLT3</i>/ITD+ Acute Myeloid Leukemia: A Report From the Children's Oncology Group Protocol AAML1031","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Cancer Institute","keywords":"Sorafenib; Chemotherapy; Standard of care; Myeloid leukemia; Myeloid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002390965,0.0006982324,0.001003569,0.0004730336,0.0004068265,0.0006395135,0.001320597,0.0008544668,0.001850641],"category_scores_gemma":[0.001767561,0.0003533119,0.0008582752,0.0006761682,0.000368336,0.0002985343,0.0003643268,0.001062247,0.0004501356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001590816,"about_ca_system_score_gemma":0.004297934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002239754,"about_ca_topic_score_gemma":0.006015103,"domain_scores_codex":[0.9986627,0.0008099662,0.0001385247,0.00008251409,0.0001958494,0.0001103997],"domain_scores_gemma":[0.9988613,0.0002531658,0.0003788512,0.00006182664,0.0001276192,0.00031713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2404816,0.01381693,0.09826585,0.007594439,0.002814416,0.00284124,0.0005579194,0.007018376,0.06067234,0.00154869,0.09300781,0.4713805],"study_design_scores_gemma":[0.3063147,0.1593443,0.3321501,0.001612379,0.002744094,0.004286108,0.000255628,0.006168714,0.02709803,0.001179173,0.1586985,0.0001482291],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8716875,0.02004783,0.006346398,0.006468161,0.0005338981,0.05200829,0.02463579,0.0004987018,0.01777339],"genre_scores_gemma":[0.8926383,0.01168265,0.01656751,0.003676017,0.0004173085,0.04844322,0.02243432,0.0001083222,0.004032449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002390965,"threshold_uncertainty_score":0.01264477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03873391942983144,"score_gpt":0.4088553898713869,"score_spread":0.3701214704415554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}