{"id":"W4220664629","doi":"10.2337/db21-1079","title":"Independent of Renox, NOX5 Promotes Renal Inflammation and Fibrosis in Diabetes by Activating ROS-Sensitive Pathways","year":2022,"lang":"en","type":"article","venue":"Diabetes","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"Steno Diabetes Center Aarhus; National Health and Medical Research Council; Medical Research Council; Monash University","keywords":"Inflammation; Diabetes mellitus; Fibrosis; Medicine; Immunology; Endocrinology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003738323,0.0003800941,0.0003196951,0.0002756281,0.0001864681,0.0003665666,0.0002325506,0.0001965723,0.002112289],"category_scores_gemma":[0.0001111993,0.0001119379,0.0004785941,0.0001681378,0.0001812818,0.0002669857,0.000300187,0.0005375773,0.0002829444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002563384,"about_ca_system_score_gemma":0.0002774442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005113215,"about_ca_topic_score_gemma":0.0005951708,"domain_scores_codex":[0.999835,0.00002785899,0.00001654259,0.00003190268,0.00004941665,0.00003920652],"domain_scores_gemma":[0.9999126,0.000005272895,0.0000295189,0.000009024187,0.00001364099,0.00002993419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006404383,0.0001023183,0.002589188,0.0002747342,0.00003726569,0.0002802768,0.00003939503,0.00009997668,0.9869365,0.0007293967,0.0001364395,0.008134111],"study_design_scores_gemma":[0.00007373375,0.000760051,0.05619645,0.00004541942,0.0001685481,0.001258471,0.0001324992,0.001631385,0.9264255,0.0005094098,0.01278134,0.00001708211],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9698731,0.0134921,0.01104058,0.0003129492,0.0001430034,0.00005369526,0.0003633267,0.0002039153,0.004517263],"genre_scores_gemma":[0.9896219,0.003749741,0.002159236,0.0001377496,0.00003906174,0.00002525356,0.0003613677,0.00001280606,0.003892995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002112289,"threshold_uncertainty_score":0.007066369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00948882320916689,"score_gpt":0.2402523894368736,"score_spread":0.2307635662277067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}