{"id":"W4220666648","doi":"10.3390/antiox11040685","title":"Enzymatic Depletion of Mitochondrial Inorganic Polyphosphate (polyP) Increases the Generation of Reactive Oxygen Species (ROS) and the Activity of the Pentose Phosphate Pathway (PPP) in Mammalian Cells","year":2022,"lang":"en","type":"article","venue":"Antioxidants","topic":"Biomedical Research and Pathophysiology","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; York University; National Institute on Aging; Rutgers Cancer Institute of New Jersey; Rutgers, The State University of New Jersey; Kitasato University","keywords":"Bioenergetics; Pentose phosphate pathway; SOD2; Oxidative phosphorylation; Oxidative stress; Mitochondrion; Glycolysis; Reactive oxygen species; Biochemistry; Cell biology; Biology; Thioredoxin; Peroxiredoxin; Superoxide dismutase; Citric acid cycle; Chemistry; Metabolism; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006920552,0.0001137149,0.0003654375,0.00007088365,0.0001461281,0.000006090264,0.0002202239,0.00005558318,0.0001728725],"category_scores_gemma":[0.0004687581,0.00005802392,0.0001051569,0.0004261656,0.0006967179,0.00005805319,0.0002402897,0.0002864045,0.000001160239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003914209,"about_ca_system_score_gemma":0.0001924875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002579106,"about_ca_topic_score_gemma":0.0002480491,"domain_scores_codex":[0.9979897,0.0007442649,0.000352011,0.0001828833,0.0005263131,0.0002048004],"domain_scores_gemma":[0.9987773,0.0004044484,0.0003359573,0.0003535564,0.00007604194,0.00005274053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001648064,0.0002805757,0.003292429,0.00008546019,0.0000488925,0.000004520723,0.0007375497,0.000002609071,0.991573,0.0003971394,0.0001280444,0.001801652],"study_design_scores_gemma":[0.002322445,0.0003082584,0.2695265,0.00005138111,0.00003880311,0.000009420531,0.0003971228,0.0002892091,0.7266542,0.0002488764,0.0001050113,0.00004868523],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971268,0.0007564091,0.00002291797,0.000964747,0.0001815934,0.0007831179,0.0001008331,0.00000386282,0.0000597599],"genre_scores_gemma":[0.9991313,0.0003747067,0.00003461545,0.0001435062,0.00007886193,0.00003580202,0.00001350238,0.00001008324,0.0001776689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2662341,"threshold_uncertainty_score":0.3898854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02157245366150273,"score_gpt":0.2496812488504093,"score_spread":0.2281087951889065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}