{"id":"W4220666648","doi":"10.3390/antiox11040685","title":"Enzymatic Depletion of Mitochondrial Inorganic Polyphosphate (polyP) Increases the Generation of Reactive Oxygen Species (ROS) and the Activity of the Pentose Phosphate Pathway (PPP) in Mammalian Cells","year":2022,"lang":"en","type":"article","venue":"Antioxidants","topic":"Biomedical Research and Pathophysiology","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; York University; National Institute on Aging; Rutgers Cancer Institute of New Jersey; Rutgers, The State University of New Jersey; Kitasato University","keywords":"Bioenergetics; Pentose phosphate pathway; SOD2; Oxidative phosphorylation; Oxidative stress; Mitochondrion; Glycolysis; Reactive oxygen species; Biochemistry; Cell biology; Biology; Thioredoxin; Peroxiredoxin; Superoxide dismutase; Citric acid cycle; Chemistry; Metabolism; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000129451,0.0004270506,0.0004267454,0.0002158601,0.0001505584,0.0004034154,0.0001970283,0.0003789483,0.0008074798],"category_scores_gemma":[0.0001339591,0.0001693135,0.0003243307,0.0002571015,0.0002557086,0.0003840915,0.00035492,0.0006835649,0.000228074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000193053,"about_ca_system_score_gemma":0.000128767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003995761,"about_ca_topic_score_gemma":0.0003472968,"domain_scores_codex":[0.9997414,0.00002022793,0.00003365438,0.00008004133,0.00008940571,0.00003533874],"domain_scores_gemma":[0.9998711,0.00001592279,0.00005411293,0.00001530771,0.00001517177,0.00002831304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004603964,0.00001501717,0.0001394142,0.00003500788,0.000005210072,0.0000359017,0.000009027808,0.00001705681,0.9993051,0.00002657604,0.00001954754,0.000346131],"study_design_scores_gemma":[0.000007233597,0.000223478,0.007572219,0.000007589353,0.00002045065,0.0003355163,0.00003467544,0.0005137104,0.989535,0.00006387875,0.001679186,0.000007112322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834006,0.004969578,0.008829145,0.0002628691,0.0001058241,0.00003563227,0.0009270689,0.0002151468,0.001254161],"genre_scores_gemma":[0.9883283,0.002872511,0.005104224,0.0001529468,0.00003457038,0.00005732608,0.001507897,0.00003292079,0.001909408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008074798,"threshold_uncertainty_score":0.002701342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02157245366150273,"score_gpt":0.2496812488504093,"score_spread":0.2281087951889065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}