{"id":"W4220671045","doi":"10.1073/pnas.2109617119","title":"α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity","year":2022,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":201,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NIHR Newcastle Biomedical Research Centre; H. Lundbeck A/S; Lundbeckfonden; Newcastle University; National Institute for Health and Care Research; Alzheimer's Society; Medical Research Council; Aarhus Universitet; University of Ottawa; European Molecular Biology Laboratory; Qatar Biomedical Research Institute, Hamad Bin Khalifa University; Universidad Nacional de Rosario","keywords":"Phosphorylation; Dementia with Lewy bodies; Fibril; Toxicity; Serine; Chemistry; Alpha-synuclein; Lewy body; Protein aggregation; Monoclonal antibody; Neurotoxicity; Cell biology; Biochemistry; Antibody; Biophysics; Parkinson's disease; Biology; Medicine; Disease; Pathology; Dementia; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001190475,0.0002916224,0.0002687766,0.0001734401,0.0001204902,0.0002156209,0.0001476725,0.0002180717,0.0005029193],"category_scores_gemma":[0.0001345921,0.0001522232,0.0002082394,0.0001078428,0.0001315423,0.0001398845,0.0001377538,0.0003593598,0.0002625405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001890954,"about_ca_system_score_gemma":0.0001303301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004862093,"about_ca_topic_score_gemma":0.0009206706,"domain_scores_codex":[0.999872,0.00001956906,0.0000157898,0.00002633735,0.0000366103,0.00002972386],"domain_scores_gemma":[0.9998645,0.0000226543,0.00004214472,0.00001424442,0.00001900342,0.00003750557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004496478,0.00002289921,0.0001089441,0.00001127687,0.000002369937,0.00001748386,0.000004228691,0.00001771351,0.9994615,0.0000104586,0.000009570285,0.0002887393],"study_design_scores_gemma":[0.000008862175,0.0003768546,0.007677401,0.000003794051,0.00000940971,0.0002297776,0.000009048712,0.0007510251,0.9905713,0.00001903938,0.0003412463,0.000002315639],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977627,0.0007233218,0.0008684727,0.00001685686,0.00000753235,0.00001426486,0.00006150472,0.00003122031,0.0005141327],"genre_scores_gemma":[0.9968484,0.0005519231,0.001225724,0.00001862715,0.000004278778,0.00001555992,0.0002652473,0.00001108403,0.001059154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005029193,"threshold_uncertainty_score":0.001682401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02562550981482111,"score_gpt":0.2805313652636308,"score_spread":0.2549058554488097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}