{"id":"W4220672160","doi":"10.1016/s1470-2045(22)00122-x","title":"Rucaparib versus standard-of-care chemotherapy in patients with relapsed ovarian cancer and a deleterious BRCA1 or BRCA2 mutation (ARIEL4): an international, open-label, randomised, phase 3 trial","year":2022,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":143,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Clovis Oncology","keywords":"Ovarian cancer; Chemotherapy; Mutation; Cancer; Phases of clinical research; Poly ADP ribose polymerase; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006291459,0.0001552838,0.0006882032,0.0001047087,0.0001419051,0.00002911624,0.0003333296,0.00007464616,0.0008857935],"category_scores_gemma":[0.00006961384,0.0001082691,0.00002416878,0.0002387026,0.0001640934,0.0001521996,0.00008416198,0.0003231709,6.360544e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008299304,"about_ca_system_score_gemma":0.0007508014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001926632,"about_ca_topic_score_gemma":0.0005330877,"domain_scores_codex":[0.9983406,0.0003805698,0.0003940563,0.0003129011,0.0003472408,0.0002246386],"domain_scores_gemma":[0.9988611,0.0002415156,0.0003351262,0.000332781,0.0001650383,0.00006444487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9522611,0.0009773719,0.0009207275,0.00002253798,0.0002198997,0.0000373069,0.00492061,0.00004633862,0.0002347183,0.0001679607,0.0006129754,0.03957841],"study_design_scores_gemma":[0.9209877,0.0383227,0.001046937,0.00004559265,0.00008400075,0.00001869244,0.0007306434,0.0001298649,0.000298087,0.00007202832,0.03812581,0.0001379242],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902804,0.0001606802,0.00005842535,0.004556688,0.0009530988,0.002835304,0.000311956,0.00002805374,0.0008154286],"genre_scores_gemma":[0.9941001,0.000272617,0.001235661,0.0024092,0.0003421936,0.001268087,0.0002643488,0.0000354712,0.00007230532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03944049,"threshold_uncertainty_score":0.9698818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07535907588749029,"score_gpt":0.4198910124240871,"score_spread":0.3445319365365968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}