{"id":"W4220673086","doi":"10.1158/1538-7445.sabcs21-p5-13-25","title":"Abstract P5-13-25: <i>PIK3CA</i> registry: A noninterventional, descriptive, retrospective cohort study of <i>PIK3CA</i> mutations in patients with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer (ABC)","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Novartis (Canada)","funders":"","keywords":"Medicine; Fulvestrant; Internal medicine; Oncology; Population; Metastatic breast cancer; Cohort; Clinical endpoint; Clinical trial; Breast cancer; Cancer; Gynecology; Estrogen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009206927,0.0006291747,0.001267478,0.0007672325,0.000933039,0.00005752399,0.0006373355,0.0001364705,0.003335125],"category_scores_gemma":[0.000201909,0.0006034528,0.0002192152,0.002565391,0.001047648,0.0007287601,0.0004137713,0.002292831,0.00001362416],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0072859,"about_ca_system_score_gemma":0.001075763,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01673643,"about_ca_topic_score_gemma":0.00297999,"domain_scores_codex":[0.9922314,0.0007936625,0.001074316,0.001552565,0.003147449,0.001200603],"domain_scores_gemma":[0.9944159,0.000317426,0.0007673235,0.0008067778,0.003301271,0.0003912734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01539903,0.005535221,0.9473712,0.0001793076,0.001345871,0.00005866453,0.008134374,0.000426887,0.01689945,0.00009393803,0.001454809,0.003101175],"study_design_scores_gemma":[0.0149085,0.004558173,0.966324,0.0006053681,0.0001028758,0.00001052684,0.009603992,0.000004907634,0.002938427,0.000143193,0.000241348,0.0005587364],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855511,0.0007611051,0.00002077846,0.0007931713,0.00025693,0.005734753,0.006131737,0.00008975068,0.0006606482],"genre_scores_gemma":[0.991293,0.0001622096,0.0002176285,0.00009857456,0.0001981357,0.006581744,0.0004625145,0.0001893292,0.0007968431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01895268,"threshold_uncertainty_score":0.9996417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02884226796859771,"score_gpt":0.3440795251232873,"score_spread":0.3152372571546896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}