{"id":"W4220673086","doi":"10.1158/1538-7445.sabcs21-p5-13-25","title":"Abstract P5-13-25: <i>PIK3CA</i> registry: A noninterventional, descriptive, retrospective cohort study of <i>PIK3CA</i> mutations in patients with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer (ABC)","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Novartis (Canada)","funders":"","keywords":"Medicine; Fulvestrant; Internal medicine; Oncology; Population; Metastatic breast cancer; Cohort; Clinical endpoint; Clinical trial; Breast cancer; Cancer; Gynecology; Estrogen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001660732,0.0004985176,0.0006563147,0.001366377,0.0009657168,0.001650449,0.001162333,0.0007087607,0.003505998],"category_scores_gemma":[0.003017716,0.0006774244,0.0008101707,0.002555087,0.0005295647,0.001131949,0.001316946,0.001050118,0.002651919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001029613,"about_ca_system_score_gemma":0.002264093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0168893,"about_ca_topic_score_gemma":0.01879861,"domain_scores_codex":[0.9979949,0.0002815928,0.0003334619,0.0007937245,0.0003551442,0.0002412027],"domain_scores_gemma":[0.9950422,0.0003834768,0.001743607,0.0009659876,0.000829723,0.001034948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004621563,0.0001861841,0.9926883,0.00008311624,0.000194952,0.0001723516,0.0001735113,0.00004917472,0.000463257,0.00005743682,0.003891247,0.001578207],"study_design_scores_gemma":[0.0001549827,0.0004000947,0.994298,0.00005918749,0.000172585,0.0006949289,0.0004048549,0.0001767694,0.0002583682,0.00003952118,0.003317981,0.00002271065],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9373838,0.0003939001,0.001024884,0.0002009051,0.0000430336,0.0006430505,0.05741623,0.00009614322,0.002798098],"genre_scores_gemma":[0.9377085,0.0003092359,0.001041585,0.0005827394,0.00007966458,0.001243118,0.05769362,0.00007794282,0.001263499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0168893,"threshold_uncertainty_score":0.03358197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02884226796859771,"score_gpt":0.3440795251232873,"score_spread":0.3152372571546896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}