{"id":"W4220675084","doi":"10.1200/jco.21.01805","title":"Phase I Study of Safety, Tolerability, and Efficacy of Tebentafusp Using a Step-Up Dosing Regimen and Expansion in Patients With Metastatic Uveal Melanoma","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Ocular Oncology and Treatments","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Dosing; Regimen; Melanoma; Metastatic melanoma; Phases of clinical research; Maximum tolerated dose","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007766567,0.000677478,0.0007482793,0.0002311789,0.0002283531,0.0003947034,0.0005043768,0.0004755163,0.001313303],"category_scores_gemma":[0.0005617518,0.0002691146,0.0004778552,0.0002273302,0.0004785198,0.0004270572,0.0001957404,0.001873957,0.0003087602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004834456,"about_ca_system_score_gemma":0.0007440145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003414321,"about_ca_topic_score_gemma":0.0009813093,"domain_scores_codex":[0.9997118,0.0001167505,0.00001322443,0.00005556586,0.0000524419,0.0000501731],"domain_scores_gemma":[0.9996332,0.00004447828,0.0001225045,0.00004561559,0.00002506809,0.000129228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1910692,0.1480843,0.02050084,0.0006854403,0.0006719782,0.0004676004,0.0005197793,0.004775249,0.4573576,0.0003150355,0.003232805,0.1723202],"study_design_scores_gemma":[0.06925847,0.8782184,0.02533577,0.00002230578,0.0001628863,0.000503675,0.00006064177,0.001519586,0.02266893,0.00009542182,0.002128635,0.00002539342],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979239,0.0004429516,0.0003796615,0.00006148152,0.00001537636,0.0006439884,0.0001315522,0.00002911705,0.0003720951],"genre_scores_gemma":[0.9960462,0.0003385287,0.001424302,0.000221383,0.00004309769,0.0007541254,0.0004500958,0.00001170901,0.0007104877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001313303,"threshold_uncertainty_score":0.004393399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08841826685890203,"score_gpt":0.4522091769482753,"score_spread":0.3637909100893733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}