{"id":"W4220675084","doi":"10.1200/jco.21.01805","title":"Phase I Study of Safety, Tolerability, and Efficacy of Tebentafusp Using a Step-Up Dosing Regimen and Expansion in Patients With Metastatic Uveal Melanoma","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Ocular Oncology and Treatments","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Dosing; Regimen; Melanoma; Metastatic melanoma; Phases of clinical research; Maximum tolerated dose","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002279356,0.0001133493,0.001559581,0.0001821919,0.00005926159,0.000001959048,0.00006462776,0.00008030095,0.00003302863],"category_scores_gemma":[0.0005304024,0.00007907128,0.00009172816,0.0001571047,0.0002045175,0.00007642544,0.0001337773,0.0005175084,7.349291e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001481558,"about_ca_system_score_gemma":0.0005389942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007072577,"about_ca_topic_score_gemma":0.00004717738,"domain_scores_codex":[0.9963341,0.001149983,0.001840075,0.0001900954,0.0003538026,0.0001319228],"domain_scores_gemma":[0.9965654,0.00140985,0.001581762,0.0001447074,0.0001570943,0.0001411662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0370697,0.03722636,0.8440006,0.00003623341,0.0006040893,0.0003702721,0.0009040165,0.00002967648,0.00004764902,0.000004173988,0.000005876449,0.07970129],"study_design_scores_gemma":[0.1239203,0.1441561,0.7287269,0.00007809361,0.001113432,0.0001461978,0.001533105,0.0001590318,0.00001389455,0.00002968209,0.00007072061,0.00005260629],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987388,0.0001729287,0.00002359577,0.0002176715,0.0001924149,0.000614459,0.000005445263,0.000001586628,0.00003313487],"genre_scores_gemma":[0.9979302,0.00002172559,0.001921534,0.00008007797,0.00002530516,0.000002349915,0.000002770344,0.000009499979,0.000006536809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1152738,"threshold_uncertainty_score":0.3224433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08841826685890203,"score_gpt":0.4522091769482753,"score_spread":0.3637909100893733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}