{"id":"W4220683091","doi":"10.51731/cjht.2022.280","title":"Osimertinib (Tagrisso)","year":2022,"lang":"en","type":"article","venue":"Canadian Journal of Health Technologies","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Osimertinib; Reimbursement; Medicine; Oncology; Lung cancer; Exon; Drug; Adjuvant; Stage (stratigraphy); Internal medicine; Family medicine; Cancer; Pharmacology; Adenocarcinoma; Political science; Gene; Biology; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003359567,0.0002296746,0.0002108181,0.0007062716,0.0001963161,0.0005203809,0.0001809082,0.0002882481,0.005884585],"category_scores_gemma":[0.0003490279,0.00004451805,0.000283499,0.0007058618,0.0001333796,0.0002324312,0.0001761803,0.0002797953,0.001343336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001964776,"about_ca_system_score_gemma":0.001963573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01560001,"about_ca_topic_score_gemma":0.0762411,"domain_scores_codex":[0.9997944,0.00002860746,0.00002101062,0.00002306062,0.0001004907,0.0000325206],"domain_scores_gemma":[0.9998691,0.00001981566,0.00004154921,0.000005055956,0.00004703256,0.00001726553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006252608,0.00006720247,0.001717859,0.001973499,0.00009388423,0.0001825229,0.00004372052,0.0002667327,0.007569182,0.002538517,0.04907983,0.9358417],"study_design_scores_gemma":[0.0003558768,0.0007906039,0.01152533,0.001022911,0.0002855309,0.001533626,0.00008103353,0.0002297199,0.008621822,0.0003982829,0.9751384,0.00001685761],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"other","genre_scores_codex":[0.06065075,0.7152902,0.0014921,0.005134962,0.0008780088,0.000356173,0.005230774,0.000339137,0.2106278],"genre_scores_gemma":[0.4829834,0.3882347,0.003824438,0.005010549,0.0003965903,0.0002148944,0.007719531,0.00004302507,0.1115729],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.01560001,"threshold_uncertainty_score":0.03101844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02514990039746959,"score_gpt":0.3347979546627587,"score_spread":0.3096480542652891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}