{"id":"W4220683438","doi":"10.1158/1538-7445.sabcs21-p2-06-03","title":"Abstract P2-06-03: Obesity is associated with DNA damage in the breast epithelium of BRCA1 and BRCA2 mutation carriers: A role for estrogens & strategies for prevention","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Nutrition, Genetics, and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Aromatase; Breast cancer; Internal medicine; Endocrinology; Estrogen; Cancer research; Biology; DNA damage; Carcinogenesis; Estrogen receptor; Cancer; Medicine; DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003069446,0.0002525395,0.0003030994,0.0004007992,0.000229009,0.0004787062,0.0002169402,0.0004581358,0.006493586],"category_scores_gemma":[0.0002537247,0.0001410615,0.000338292,0.0003290068,0.000172005,0.0001579968,0.0002250562,0.0006639276,0.0008469514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001949819,"about_ca_system_score_gemma":0.0002317107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006102924,"about_ca_topic_score_gemma":0.0006449693,"domain_scores_codex":[0.9999139,0.00001669759,0.000005569964,0.00002248218,0.00002534962,0.00001589104],"domain_scores_gemma":[0.9997935,0.00003177262,0.00007900181,0.00001393364,0.00003341509,0.00004841758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01131452,0.0008305577,0.2045263,0.0009436756,0.0002672041,0.001918553,0.0001576558,0.0002285227,0.713378,0.0003276491,0.006925947,0.05918156],"study_design_scores_gemma":[0.0001384291,0.002319021,0.9205933,0.0001389007,0.0002460751,0.004220092,0.0002828958,0.0006682477,0.06000108,0.0003565856,0.01101333,0.00002210153],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853444,0.007660666,0.001136573,0.001284699,0.0001308736,0.00006298713,0.002481627,0.00006648783,0.001831747],"genre_scores_gemma":[0.9855072,0.004017116,0.00172095,0.0004852344,0.0001275944,0.00008252647,0.002756376,0.00003858241,0.005264393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006493586,"threshold_uncertainty_score":0.02172327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03582186595310973,"score_gpt":0.3532125263163675,"score_spread":0.3173906603632578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}