{"id":"W4220683899","doi":"10.1038/s41598-022-06198-4","title":"Primary glia cells from bank vole propagate multiple rodent-adapted scrapie prions","year":2022,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Alberta Prion Research Institute; Robert Koch Institut; Istituto Superiore di Sanità; Bundesministerium für Bildung und Forschung","keywords":"Bank vole; Scrapie; Hamster; Vole; Biology; In vitro; Rodent; In vivo; Cell; Cell biology; Virology; Immunology; Molecular biology; Genetics; Prion protein; Disease; Pathology; Ecology; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001319965,0.0004930997,0.0003182931,0.0004382663,0.0002691218,0.0004295836,0.0001683712,0.0002398764,0.001466103],"category_scores_gemma":[0.0001015059,0.0001316111,0.0003027926,0.0002152636,0.0002536021,0.0001793382,0.0002889051,0.0003859149,0.001038898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001243611,"about_ca_system_score_gemma":0.000139667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001345701,"about_ca_topic_score_gemma":0.00368318,"domain_scores_codex":[0.9998498,0.00001785837,0.00002348298,0.00005282542,0.00002596609,0.00003001254],"domain_scores_gemma":[0.999863,0.00002163122,0.00002352637,0.00003025194,0.00002475884,0.00003677392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006953205,0.00002146298,0.001257838,0.00004099246,0.00001099417,0.0001917048,0.00007594717,0.00002037329,0.9973362,0.0000555556,0.00005807814,0.0008613068],"study_design_scores_gemma":[0.000008048587,0.0005166179,0.02630671,0.00002629747,0.00006224477,0.001245221,0.0002443418,0.0002591438,0.9677119,0.000096216,0.003514037,0.000009108744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888642,0.001516134,0.0045176,0.00007348235,0.00005130403,0.00005069095,0.001401865,0.0001065382,0.00341827],"genre_scores_gemma":[0.9787331,0.002053911,0.007788712,0.0001074222,0.00002069875,0.00007748073,0.002817759,0.00006137208,0.008339541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001466103,"threshold_uncertainty_score":0.004904568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008649094519224862,"score_gpt":0.2112106541347358,"score_spread":0.2025615596155109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}