{"id":"W4220684155","doi":"10.1016/j.omto.2022.03.006","title":"IFNAR blockade synergizes with oncolytic VSV to prevent virus-mediated PD-L1 expression and promote antitumor T cell activity","year":2022,"lang":"en","type":"article","venue":"Molecular Therapy — Oncolytics","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; McMaster University Medical Centre","funders":"","keywords":"Oncolytic virus; Virotherapy; Blockade; Immunotherapy; Cancer research; Monoclonal antibody; Interferon; Virology; Immunity; Immunology; Immune system; Virus; Biology; Antibody; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001521351,0.00040933,0.0004054852,0.0002089958,0.000118233,0.0003495499,0.0002144205,0.0002641802,0.00130905],"category_scores_gemma":[0.0000850335,0.0001035593,0.0002626632,0.0001256426,0.0001932023,0.0002128179,0.0001241058,0.0009785887,0.0003186326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003444898,"about_ca_system_score_gemma":0.0003852436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003133289,"about_ca_topic_score_gemma":0.0008719662,"domain_scores_codex":[0.9998425,0.00003119036,0.00001341166,0.00002171209,0.00003489059,0.00005617579],"domain_scores_gemma":[0.9999455,0.00001407322,0.00001111448,0.000008120181,0.000004013988,0.00001710777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001114447,0.0005916915,0.0002721603,0.00007251121,0.00002819891,0.00004995214,0.0000229191,0.0006812143,0.9854118,0.0004044318,0.0002906657,0.01105999],"study_design_scores_gemma":[0.0002372605,0.003298917,0.001981833,0.000009099364,0.0000379579,0.000252966,0.00001784276,0.002693651,0.9869515,0.0001479596,0.004364506,0.000006473662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913078,0.002462367,0.002497078,0.0001742207,0.0001433923,0.00007287831,0.00027281,0.0001593865,0.002910181],"genre_scores_gemma":[0.9955363,0.0008513627,0.001369692,0.00007438025,0.00003421148,0.00006007983,0.0002692699,0.00001576646,0.001788925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00130905,"threshold_uncertainty_score":0.004379153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01052956169326307,"score_gpt":0.2695364468724535,"score_spread":0.2590068851791905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}