{"id":"W4220685594","doi":"10.1021/acs.jmedchem.1c02122","title":"Potent Bactericidal Antimycobacterials Targeting the Chaperone ClpC1 Based on the Depsipeptide Natural Products Ecumicin and Ohmyungsamycin A","year":2022,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Health Research Council of New Zealand; Australian Research Council","keywords":"Depsipeptide; Chemistry; Mycobacterium tuberculosis; Natural product; In vitro; In vivo; Antimycobacterial; Biological activity; Microbiology; Protease; Tuberculosis; Biochemistry; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009675186,0.0003935566,0.0003006192,0.0002191823,0.00009667679,0.0002175479,0.000222078,0.0001890098,0.0008677072],"category_scores_gemma":[0.0001064484,0.0001261573,0.0001475228,0.0001761371,0.0001485555,0.0001590759,0.0002095805,0.0003622715,0.0002478269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001887296,"about_ca_system_score_gemma":0.0001674845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001957297,"about_ca_topic_score_gemma":0.0007094645,"domain_scores_codex":[0.9999439,0.00000996862,0.000004779248,0.00001185647,0.00001614926,0.00001342158],"domain_scores_gemma":[0.999954,0.000005403261,0.00001513484,0.000004311394,0.000007871954,0.00001334373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002015313,0.0000876581,0.0002051634,0.0001500084,0.00001038671,0.000188554,0.00003582144,0.000632254,0.9866726,0.000212886,0.0001262091,0.01147696],"study_design_scores_gemma":[0.0002526247,0.005870564,0.003863551,0.00003504526,0.00006633105,0.0009809448,0.00005209473,0.001503076,0.9685689,0.0001373901,0.0186437,0.00002569256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816004,0.006541524,0.006223611,0.00009460054,0.00004576835,0.0002912574,0.0005133495,0.0001181832,0.00457133],"genre_scores_gemma":[0.986696,0.003512356,0.006321837,0.00009760899,0.00001695499,0.0001228436,0.0006793472,0.00001438421,0.002538609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008677072,"threshold_uncertainty_score":0.002902746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007657092613325403,"score_gpt":0.2079113377777562,"score_spread":0.2002542451644308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}