{"id":"W4220688343","doi":"10.1080/10428194.2022.2043299","title":"Lenalidomide enhances CD23.CAR T cell therapy in chronic lymphocytic leukemia","year":2022,"lang":"en","type":"article","venue":"Leukemia & lymphoma/Leukemia and lymphoma","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Cancer Institute; Celgene; CLL Global Research Foundation","keywords":"Lenalidomide; Chronic lymphocytic leukemia; Chimeric antigen receptor; CD23; Cancer research; T cell; Antigen; Immunology; Leukemia; Medicine; Immune system; Multiple myeloma; Immunoglobulin E; Antibody","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.001671336,0.001336665,0.001943758,0.001280395,0.001015026,0.0002568287,0.0012001,0.0005936328,0.004912664],"category_scores_gemma":[0.00009995303,0.001326796,0.0006997241,0.002259709,0.0007399745,0.0004839008,0.0008789208,0.0007532369,0.0002356629],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.1823684,"about_ca_system_score_gemma":0.04546049,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009675176,"about_ca_topic_score_gemma":0.0003155854,"domain_scores_codex":[0.9905021,0.000766954,0.001651239,0.002256461,0.002296342,0.002526892],"domain_scores_gemma":[0.995739,0.000711002,0.0004964091,0.001895641,0.000207127,0.0009508332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.009147414,0.0003689761,0.004076359,0.0007071048,0.0005127616,0.003327858,0.003466466,0.00407221,0.593725,0.0003947697,0.0077624,0.3724387],"study_design_scores_gemma":[0.1373335,0.005845741,0.03205408,0.0005499504,0.0003346924,0.005577256,0.003575561,0.04947293,0.3247698,0.0009933906,0.4359661,0.003527016],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9607244,0.01678673,0.00002674285,0.0001842326,0.0006958763,0.002012082,0.00006975009,0.0004481219,0.0190521],"genre_scores_gemma":[0.959233,0.009762021,0.0002230688,0.002504098,0.0009389372,0.001117977,0.0002147359,0.0003540877,0.02565206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4282037,"threshold_uncertainty_score":0.9999384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01615558200279773,"score_gpt":0.2681936132045368,"score_spread":0.2520380312017391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}