{"id":"W4220690679","doi":"10.3390/membranes12040359","title":"Evaluation of Host Cell Impurity Effects on the Performance of Sterile Filtration Processes for Therapeutic Viruses","year":2022,"lang":"en","type":"article","venue":"Membranes","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; McMaster University","keywords":"Microfiltration; Filtration (mathematics); Membrane; Chromatography; Vesicular stomatitis virus; Ultrafiltration (renal); Membrane fouling; Cell disruption; Fouling; Cross-flow filtration; Chemistry; Virus; Biology; Virology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001105303,0.00007388557,0.00008641763,0.00002893541,0.0001210524,0.000005914409,0.0001776621,0.00002734438,0.00005618006],"category_scores_gemma":[0.00007246181,0.00005510253,0.00004228541,0.0001042016,0.00004001192,0.000003351357,0.00003295275,0.00004391064,5.936417e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001197033,"about_ca_system_score_gemma":0.0001980846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004330947,"about_ca_topic_score_gemma":0.00001861901,"domain_scores_codex":[0.9990078,0.0002717478,0.0001209257,0.0001409667,0.0003564878,0.0001020857],"domain_scores_gemma":[0.999328,0.00008929064,0.00009270365,0.0002267613,0.0002519784,0.00001126367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001152218,0.00009939492,0.000259428,0.0003989422,0.00003080549,2.192242e-8,0.0001074314,0.001458415,0.9923908,0.000002685821,0.00005146108,0.004048384],"study_design_scores_gemma":[0.0005559779,0.004775744,0.0006109657,0.000008366769,0.0000289913,4.831448e-7,0.00005771024,0.001028373,0.9921392,0.00002939526,0.000705911,0.00005888149],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971432,0.001809324,0.00001227905,0.00008671062,0.00005149778,0.0007585416,0.00004062022,0.000003361942,0.00009447738],"genre_scores_gemma":[0.9991531,0.0001428033,0.000007753048,0.0001340243,0.00004890175,0.0004206153,0.00003455491,0.00001226755,0.00004594218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004676349,"threshold_uncertainty_score":0.2247016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03997356256838245,"score_gpt":0.3168900850848405,"score_spread":0.276916522516458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}