{"id":"W4220690679","doi":"10.3390/membranes12040359","title":"Evaluation of Host Cell Impurity Effects on the Performance of Sterile Filtration Processes for Therapeutic Viruses","year":2022,"lang":"en","type":"article","venue":"Membranes","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; McMaster University","keywords":"Microfiltration; Filtration (mathematics); Membrane; Chromatography; Vesicular stomatitis virus; Ultrafiltration (renal); Membrane fouling; Cell disruption; Fouling; Cross-flow filtration; Chemistry; Virus; Biology; Virology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001502175,0.0005521707,0.0004524414,0.0002662374,0.0002627291,0.0006853796,0.0003067486,0.0006843164,0.0003588043],"category_scores_gemma":[0.002544401,0.0002071012,0.0003856314,0.0002224573,0.0003459594,0.0005616308,0.0003667077,0.0006131633,0.0001847469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003039078,"about_ca_system_score_gemma":0.0002439684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006915221,"about_ca_topic_score_gemma":0.0005331816,"domain_scores_codex":[0.9987215,0.0003093258,0.0001054979,0.0001504437,0.000559363,0.0001539048],"domain_scores_gemma":[0.998665,0.0005967307,0.0002801811,0.00009709438,0.0003139618,0.00004715258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005865127,0.00001931809,0.00036556,0.00004825888,0.000009459383,0.00003712176,0.00004168139,0.0001135668,0.9976158,0.0000269009,0.00001572638,0.001647892],"study_design_scores_gemma":[0.000001286301,0.0001726772,0.001500944,0.000003589461,0.00001161497,0.00004485631,0.00002076344,0.000678745,0.9972607,0.000009481172,0.0002896883,0.00000557564],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841002,0.001411535,0.01362026,0.0000726713,0.00002686898,0.00005353404,0.0001273799,0.0001123665,0.000475085],"genre_scores_gemma":[0.9836769,0.001221046,0.01388595,0.00007244488,0.00001303836,0.00006029041,0.0002959467,0.00005548865,0.0007189643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001502175,"threshold_uncertainty_score":0.007944345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03997356256838245,"score_gpt":0.3168900850848405,"score_spread":0.276916522516458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}