{"id":"W4220691480","doi":"10.1016/j.bbalip.2022.159156","title":"PD146176 affects human EA.hy926 endothelial cell function by differentially modulating oxylipin production of LOX, COX and CYP epoxygenase","year":2022,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"Canadian Institutes of Health Research","keywords":"Epoxygenase; Oxylipin; Cell biology; Endothelial stem cell; Biology; Chemistry; Biochemistry; Cytochrome P450; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002706094,0.0003753008,0.0004067254,0.0002192942,0.0001977631,0.0003563584,0.0003257003,0.0004463294,0.004156317],"category_scores_gemma":[0.0001756136,0.0002041074,0.0003565705,0.0002701099,0.000248813,0.000197526,0.0001641386,0.0007630145,0.0008327751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001944867,"about_ca_system_score_gemma":0.0002804352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008279852,"about_ca_topic_score_gemma":0.001045516,"domain_scores_codex":[0.9997473,0.00005259181,0.00002954768,0.00004080166,0.00004088787,0.00008883679],"domain_scores_gemma":[0.9999317,0.00001358031,0.00001636218,0.00001077646,0.000005805088,0.00002175149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002877444,0.000580603,0.0004367928,0.00005192764,0.00003180503,0.000337981,0.00002783762,0.0001235554,0.9920784,0.0002366374,0.0002767406,0.002940357],"study_design_scores_gemma":[0.0007580293,0.006348051,0.01079976,0.00001191488,0.0001479596,0.001100314,0.0001128677,0.001154156,0.973582,0.0001314923,0.005835611,0.00001791243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961074,0.0008010197,0.0006444964,0.0001435611,0.0000976768,0.00003234229,0.0006326651,0.00006294424,0.001477929],"genre_scores_gemma":[0.9933729,0.0008609839,0.0005604341,0.0001328119,0.00002896144,0.00006000259,0.0009238066,0.00001808949,0.004041844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004156317,"threshold_uncertainty_score":0.01390427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00613285218502275,"score_gpt":0.2268239988345446,"score_spread":0.2206911466495219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}