{"id":"W4220691696","doi":"10.3389/fbioe.2022.866275","title":"Targeted Codelivery of Prodigiosin and Simvastatin Using Smart BioMOF: Functionalization by Recombinant Anti-VEGFR1 scFv","year":2022,"lang":"en","type":"article","venue":"Frontiers in Bioengineering and Biotechnology","topic":"Microbial Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Technische Universität Berlin; Canada Research Chairs; Deutsche Forschungsgemeinschaft","keywords":"Chemistry; Nanocarriers; Simvastatin; Cytotoxic T cell; Cancer cell; Cancer research; Prodigiosin; Drug delivery; Biochemistry; Pharmacology; Molecular biology; Cancer; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001122532,0.00009966264,0.0001492242,0.0001659957,0.00007660547,0.000005342892,0.00007276078,0.0001216462,0.000002292505],"category_scores_gemma":[0.0000203251,0.0001089312,0.00001798101,0.0002476788,0.0001025176,0.000004600225,0.0001255438,0.0000922699,5.820998e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001345541,"about_ca_system_score_gemma":0.00001606952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003186706,"about_ca_topic_score_gemma":6.917604e-7,"domain_scores_codex":[0.9993806,0.00002290204,0.0001694823,0.0002251646,0.00004436273,0.0001574326],"domain_scores_gemma":[0.9997745,0.000002897335,0.00006120124,0.0001212328,0.00001529613,0.00002491055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001988969,0.00004947999,0.003014139,0.00002463731,0.00001837443,2.9538e-7,0.00001755187,0.000372817,0.9919559,0.00009857202,0.002375953,0.002052388],"study_design_scores_gemma":[0.0007822334,0.0001835769,0.001390083,0.00001679431,0.00002654015,0.0000486924,0.0003987836,0.01247362,0.9153541,0.00008516509,0.06892125,0.000319195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9398267,0.007021527,0.05241687,0.000159963,0.0002914534,0.0001514111,0.0001101914,0.00001904049,0.000002867803],"genre_scores_gemma":[0.9879848,0.001221473,0.01054605,0.00003010988,0.0000144598,0.00001910844,0.0001384272,0.00001324304,0.00003230106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07660184,"threshold_uncertainty_score":0.4442084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004450034158997062,"score_gpt":0.1895198868444896,"score_spread":0.1850698526854926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}