{"id":"W4220691719","doi":"10.1161/jaha.121.023021","title":"Platelet‐Derived Growth Factor Receptor Type α Activation Drives Pulmonary Vascular Remodeling Via Progenitor Cell Proliferation and Induces Pulmonary Hypertension","year":2022,"lang":"en","type":"article","venue":"Journal of the American Heart Association","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Institut de Cardiométabolisme et Nutrition; Fondation Leducq; Australian Research Council; Medical Research Council; Canadian Institutes of Health Research; New South Wales Government; Laboratoire d'Excellence en Recherche sur le Médicament et l'Innovation Thérapeutique; Fondation pour la Recherche Médicale; National Health and Medical Research Council; Agence Nationale de la Recherche; Acceleron; GlaxoSmithKline","keywords":"Progenitor cell; Pulmonary hypertension; Vascular smooth muscle; Lung; Vascular remodelling in the embryo; Progenitor; Kinase insert domain receptor; Endothelial stem cell; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001846201,0.0001967716,0.0002301764,0.00016513,0.000148645,0.0002406342,0.0001554944,0.0002284733,0.001234388],"category_scores_gemma":[0.0001177182,0.0001330645,0.0002094269,0.0001437985,0.0002266629,0.0001158961,0.0001903721,0.0007540222,0.0004107383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001997611,"about_ca_system_score_gemma":0.000145617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002761382,"about_ca_topic_score_gemma":0.0003692633,"domain_scores_codex":[0.9997752,0.00003972259,0.0000233624,0.00003539455,0.00006698768,0.00005931306],"domain_scores_gemma":[0.9998326,0.00004379569,0.00004122673,0.00002384182,0.000009557273,0.0000489292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009855762,0.00006130897,0.0001945666,0.00002360995,0.000002507397,0.0000690306,0.00001691726,0.00003625642,0.9984779,0.0001090088,0.00004648554,0.0008639843],"study_design_scores_gemma":[0.0000469802,0.0006749522,0.006850779,0.000008498561,0.00001450818,0.0004889687,0.00004131617,0.001170232,0.9884532,0.00007493174,0.00217244,0.000003149937],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959944,0.0005627153,0.001835092,0.00009265661,0.0000243759,0.00003453645,0.0002318585,0.0000628554,0.001161392],"genre_scores_gemma":[0.9959152,0.0005717036,0.001097233,0.00005758425,0.00001968459,0.00007058748,0.0003879732,0.00001467796,0.001865224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001234388,"threshold_uncertainty_score":0.00412941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02113574949245249,"score_gpt":0.2599408481969303,"score_spread":0.2388050987044778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}