{"id":"W4220692116","doi":"10.1128/mbio.03209-21","title":"PixR, a Novel Activator of Conjugative Transfer of IncX4 Resistance Plasmids, Mitigates the Fitness Cost of <i>mcr-1</i> Carriage in Escherichia coli","year":2022,"lang":"en","type":"article","venue":"mBio","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Higher Education Discipline Innovation Project; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China; Government of Canada","keywords":"Plasmid; Carriage; Escherichia coli; Antibiotic resistance; Biology; Horizontal gene transfer; Microbiology; Gene; Genetics; Antibiotics; Medicine; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002642841,0.0001410964,0.0003061394,0.00003212652,0.0000552157,0.000004393091,0.0003662378,0.00008382412,0.00005051208],"category_scores_gemma":[0.00008463216,0.0001224927,0.00008984585,0.0002408402,0.0004313361,0.00000473322,0.0001147313,0.0001381253,2.057747e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002683352,"about_ca_system_score_gemma":0.0001616104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000982562,"about_ca_topic_score_gemma":0.0002272975,"domain_scores_codex":[0.9988285,0.0001326498,0.0004136937,0.000247918,0.0001992435,0.0001779794],"domain_scores_gemma":[0.9992539,0.00007558149,0.0001819669,0.0003661187,0.00009363423,0.00002878857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000758698,0.0001803332,0.009242482,0.0001045742,0.00006672089,0.000001333349,0.0004247577,0.00003682526,0.9879914,0.0007682971,0.0004045347,0.00002007719],"study_design_scores_gemma":[0.001051702,0.0001576354,0.02535544,0.00005757107,0.00001803378,0.000001042706,0.001143738,0.00001258125,0.9677472,0.00004418617,0.004282626,0.0001282618],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974226,0.0003241013,0.0002422709,0.0001242631,0.0001042328,0.000394655,0.0007686685,0.000002927236,0.0006162402],"genre_scores_gemma":[0.999159,0.00004695111,0.0002637544,0.00007476491,0.00001890592,0.00003279935,0.00006007635,0.00001973653,0.0003240611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02024418,"threshold_uncertainty_score":0.4995107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01016677629593624,"score_gpt":0.2312619368343843,"score_spread":0.221095160538448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}