{"id":"W4220692116","doi":"10.1128/mbio.03209-21","title":"PixR, a Novel Activator of Conjugative Transfer of IncX4 Resistance Plasmids, Mitigates the Fitness Cost of <i>mcr-1</i> Carriage in Escherichia coli","year":2022,"lang":"en","type":"article","venue":"mBio","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Higher Education Discipline Innovation Project; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China; Government of Canada","keywords":"Plasmid; Carriage; Escherichia coli; Antibiotic resistance; Biology; Horizontal gene transfer; Microbiology; Gene; Genetics; Antibiotics; Medicine; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002177399,0.0003566545,0.0004831981,0.0002576741,0.0001561117,0.0005148982,0.0004174359,0.0002700865,0.00133462],"category_scores_gemma":[0.0001500171,0.0001749591,0.0002318199,0.000118176,0.0002715108,0.000201151,0.0003358465,0.0006119647,0.0003789978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002077858,"about_ca_system_score_gemma":0.0002698002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001264184,"about_ca_topic_score_gemma":0.0002575397,"domain_scores_codex":[0.9998825,0.00001998377,0.000009310098,0.00002804596,0.0000352043,0.00002509348],"domain_scores_gemma":[0.9999487,0.000009891147,0.00001378701,0.000005230025,0.00000410617,0.00001821599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002557848,0.00008800991,0.0002231486,0.00009339186,0.00001155654,0.00009997054,0.00001458063,0.0003380309,0.9890703,0.0005211464,0.000226462,0.009057658],"study_design_scores_gemma":[0.0001470834,0.001330251,0.002692879,0.0000129974,0.00004844417,0.0005218753,0.00003667826,0.004187043,0.9777821,0.0001775163,0.01304031,0.00002275527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9748286,0.005781418,0.01079871,0.000500519,0.0001347596,0.000101859,0.0002641152,0.0007977497,0.006792189],"genre_scores_gemma":[0.9794329,0.003142096,0.01130314,0.0002188199,0.00006854439,0.00007354568,0.0004412669,0.0001129076,0.005206845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00133462,"threshold_uncertainty_score":0.004464686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01016677629593624,"score_gpt":0.2312619368343843,"score_spread":0.221095160538448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}