{"id":"W4220694174","doi":"10.1126/science.abm5320","title":"The histone H3.1 variant regulates TONSOKU-mediated DNA repair during replication","year":2022,"lang":"en","type":"article","venue":"Science","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Fonds de recherche du Québec – Nature et technologies; Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; Yale University; National Institutes of Health; Wellcome Trust; National Institute of General Medical Sciences; Directorate for Biological Sciences; University of Ottawa; University of Toronto","keywords":"Histone H3; Biology; DNA replication; Origin recognition complex; Replication factor C; Control of chromosome duplication; Genetics; Cell biology; Histone; Genome instability; Eukaryotic DNA replication; DNA; DNA damage","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008934116,0.0001944752,0.0001332902,0.0001175424,0.0001760486,0.0002498018,0.0002118286,0.000166982,0.001213342],"category_scores_gemma":[0.0001062096,0.0001325265,0.0001560295,0.00006936827,0.0002915106,0.0001471434,0.0002505391,0.0003082384,0.0003592128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003919181,"about_ca_system_score_gemma":0.0001545861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00090685,"about_ca_topic_score_gemma":0.001312973,"domain_scores_codex":[0.9999,0.0000145383,0.000006310725,0.00003195268,0.0000185267,0.00002869803],"domain_scores_gemma":[0.9998763,0.00001582423,0.00004753691,0.00001042442,0.00001072258,0.00003915959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007417701,0.000004415193,0.0002964637,0.000005661084,0.000001256268,0.00001551509,0.000007432496,0.00002043552,0.9992305,0.0000437384,0.000008347891,0.0002920242],"study_design_scores_gemma":[0.000009967579,0.00007468573,0.01819337,0.000003377091,0.000006074075,0.0001239853,0.00004405223,0.001230578,0.9795904,0.00006194493,0.0006551284,0.000006451935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981311,0.0002652175,0.0009196401,0.00002545356,0.000008851787,0.000005115347,0.00008959346,0.00004705915,0.0005080144],"genre_scores_gemma":[0.998875,0.00005881133,0.0002259288,0.00001001316,0.000001278529,0.000003857509,0.00008591857,0.00001394869,0.0007251184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001213342,"threshold_uncertainty_score":0.004059017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004238254256210153,"score_gpt":0.2257718444412653,"score_spread":0.2215335901850551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}