{"id":"W4220694174","doi":"10.1126/science.abm5320","title":"The histone H3.1 variant regulates TONSOKU-mediated DNA repair during replication","year":2022,"lang":"en","type":"article","venue":"Science","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Fonds de recherche du Québec – Nature et technologies; Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; Yale University; National Institutes of Health; Wellcome Trust; National Institute of General Medical Sciences; Directorate for Biological Sciences; University of Ottawa; University of Toronto","keywords":"Histone H3; Biology; DNA replication; Origin recognition complex; Replication factor C; Control of chromosome duplication; Genetics; Cell biology; Histone; Genome instability; Eukaryotic DNA replication; DNA; DNA damage","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007530574,0.00006177901,0.00004412164,0.00002495886,0.001152856,0.00003381196,0.000474724,0.00001972696,0.0000117113],"category_scores_gemma":[0.0001722191,0.00005158468,0.0000380125,0.000235506,0.0002481182,0.000003278364,0.0004058965,0.00006094772,0.000004211055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007808878,"about_ca_system_score_gemma":0.0001562248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009233459,"about_ca_topic_score_gemma":0.00001033841,"domain_scores_codex":[0.9990547,0.00002918542,0.0001357758,0.0003801001,0.0001926291,0.0002076295],"domain_scores_gemma":[0.9990316,0.00001010715,0.00008298667,0.0007766083,0.00005250147,0.00004619415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001124018,0.00001470285,0.0001747301,0.000002004364,0.000003938233,0.000001583358,0.00005504291,0.0002831858,0.998531,0.0003843099,0.0002498131,0.0002884178],"study_design_scores_gemma":[0.0007523951,0.0004679025,0.1559191,0.000007762555,0.00002165715,0.0003446312,0.0009123787,0.02763664,0.5882053,0.001508732,0.223573,0.0006504247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982788,0.000369427,0.00002803385,0.0004085356,0.000200689,0.0001050038,0.00001072056,0.00002280056,0.0005759804],"genre_scores_gemma":[0.9974015,0.00006354782,0.0003630081,0.00009076217,0.00003828023,0.00003480016,0.00002886058,0.000007435688,0.001971798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4103257,"threshold_uncertainty_score":0.8866955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004238254256210153,"score_gpt":0.2257718444412653,"score_spread":0.2215335901850551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}