{"id":"W4220696155","doi":"10.21203/rs.3.rs-1188941/v2","title":"Differential Impairment Of Cerebrospinal Fluid Synaptic Biomarkers In The Genetic Forms Of Frontotemporal Dementia","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Western University; University of Toronto; Université Laval","funders":"NIHR Cambridge Biomedical Research Centre; Medical Research Council; Canadian Institutes of Health Research; Tau Consortium; Olav Thon Stiftelsen; UK Dementia Research Institute; Stockholms Läns Landsting; Familjen Erling-Perssons Stiftelse; European Commission; Hjärnfonden; Vetenskapsrådet; Alzheimer's Society; Ministero della Salute; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Wolfson Foundation; Stichting Dioraphte; University of Cambridge; National Brain Appeal; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; ZonMw; Weston Brain Institute; Alzheimer's Drug Discovery Foundation; Brain Research UK; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Alzheimer Nederland; EU Joint Programme – Neurodegenerative Disease Research; Stiftelsen för Gamla Tjänarinnor; Alzheimer's Association","keywords":"Frontotemporal dementia; C9orf72; Neurogranin; Biology; Cerebrospinal fluid; Neuroscience; Genetics; Medicine; Dementia; Internal medicine; Disease; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009447523,0.000656385,0.0003908855,0.001252154,0.0002755065,0.0005764153,0.0003266332,0.0005332525,0.0009712119],"category_scores_gemma":[0.002562999,0.0001615503,0.000253444,0.0004729022,0.0003822577,0.0003815525,0.000418569,0.0003072936,0.0002607564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003676816,"about_ca_system_score_gemma":0.0002418608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001978357,"about_ca_topic_score_gemma":0.001398016,"domain_scores_codex":[0.9996038,0.00007932107,0.00004112463,0.0001019189,0.0001313548,0.00004258524],"domain_scores_gemma":[0.9992337,0.0002113018,0.0002704682,0.00005615626,0.0001382776,0.00009006821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00183406,0.0002138743,0.9426159,0.00006592886,0.0002048099,0.001843359,0.0003112776,0.0004304427,0.03880524,0.00009003942,0.0002680935,0.01331696],"study_design_scores_gemma":[0.00001994736,0.0004752018,0.9863089,0.00002038001,0.00008424414,0.003371421,0.0001880685,0.001682847,0.007407295,0.0002193409,0.0002105922,0.00001162503],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991688,0.0001593099,0.0003028254,0.00001530218,0.000004990342,0.000004606856,0.0001348395,0.00001814092,0.0001912511],"genre_scores_gemma":[0.9994292,0.00003841635,0.0003018789,0.00001142822,0.000003505575,0.000004848745,0.0001405056,0.000003495659,0.00006683301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001978357,"threshold_uncertainty_score":0.004996359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05722518307696728,"score_gpt":0.3804381898987449,"score_spread":0.3232130068217776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}