{"id":"W4220697184","doi":"10.3390/computation10040051","title":"In Silico Analysis of the Multi-Targeted Mode of Action of Ivermectin and Related Compounds","year":2022,"lang":"en","type":"article","venue":"Computation","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"In silico; Ivermectin; Docking (animal); Infectivity; Mode of action; Chemistry; Virus; Binding site; Receptor; Cholinergic; Mechanism of action; Biology; Pharmacology; Virology; Biochemistry; In vitro; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000077945,0.00004011862,0.000174764,0.000166373,0.00005879658,8.980243e-7,0.00004629575,0.00003525525,0.00004826585],"category_scores_gemma":[0.00001153144,0.00003532114,0.00005937227,0.0004016691,0.0001033385,0.00003682672,0.00005636239,0.00009455672,2.182002e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001813975,"about_ca_system_score_gemma":0.00001375844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006968954,"about_ca_topic_score_gemma":0.00008378292,"domain_scores_codex":[0.9995041,0.0001535121,0.0002004017,0.00007551416,0.00001901274,0.00004746648],"domain_scores_gemma":[0.999624,0.00006933579,0.0002204359,0.00005469913,0.00002952617,0.00000198005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00006483246,0.0001160027,0.01483848,0.00001381673,0.0002556971,1.002553e-7,0.00178756,0.08512622,0.8969879,0.000111007,0.00006424316,0.0006341424],"study_design_scores_gemma":[0.001538291,0.0001457167,0.5159241,0.00001867147,0.0003677407,0.000007892323,0.002598397,0.06397407,0.4149052,0.00036529,0.00005217295,0.0001024524],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992139,0.0001382185,0.0003375907,0.00003516057,0.0001280586,0.00007278238,0.00003767581,0.000004106299,0.00003252579],"genre_scores_gemma":[0.9997495,0.000006559108,0.00006017067,0.000008783114,7.543305e-7,0.000001427683,0.00006059869,0.000002458818,0.0001097586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5010856,"threshold_uncertainty_score":0.1440354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01462260943404378,"score_gpt":0.2626417169363084,"score_spread":0.2480191075022646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}